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Feeding Spray-Dried Porcine Plasma to Pigs Reduces African Swine Fever Virus Load in Infected Pigs and Delays Virus Transmission—Study 1
dc.contributor.author | Blázquez, Elena | |
dc.contributor.author | Pujols, Joan | |
dc.contributor.author | Rodriguez, Fernando | |
dc.contributor.author | Segalés, Joaquim | |
dc.contributor.author | Rosell, Rosa | |
dc.contributor.author | Campbell, Joy | |
dc.contributor.author | Polo, Javier | |
dc.contributor.other | Producció Animal | ca |
dc.date.accessioned | 2023-09-29T07:35:40Z | |
dc.date.available | 2023-09-29T07:35:40Z | |
dc.date.issued | 2023-04-10 | |
dc.identifier.citation | Blázquez, Elena, Joan Pujols, Fernando Rodríguez, Joaquim Segalés, Rosa Rosell, Joy Campbell, and Javier Polo. 2023. "Feeding Spray-Dried Porcine Plasma To Pigs Reduces African Swine Fever Virus Load In Infected Pigs And Delays Virus Transmission—Study 1". Vaccines 11 (4): 824. doi:10.3390/vaccines11040824. | ca |
dc.identifier.issn | 2076-393X | ca |
dc.identifier.uri | http://hdl.handle.net/20.500.12327/2371 | |
dc.description.abstract | The objective of this study was to evaluate the potential benefits of feeding spray-dried porcine plasma (SDPP) to pigs infected with African swine fever virus (ASFV). Two groups of twelve weaned pigs each were fed with CONVENTIONAL or 8% SDPP enriched diets. Two pigs (trojans)/group) were injected intramuscularly with the pandemic ASFV (Georgia 2007/01) and comingled with the rest of the pigs (1:5 trojan:naïve ratio) to simulate a natural route of transmission. Trojans developed ASF and died within the first week after inoculation, but contact pigs did not develop ASF, viremia, or seroconversion. Therefore, three more trojans per group were introduced to optimize the ASFV transmission (1:2 trojan:naïve ratio). Blood, nasal, and rectal swabs were weekly harvested, and at end of the study ASFV-target organs collected. After the second exposure, rectal temperature of conventionally fed contact pigs increased >40.5 °C while fever was delayed in the SDPP contact pigs. Additionally, PCR Ct values in blood, secretions, and tissue samples were significantly lower (p < 0.05) for CONVENTIONAL compared to SDPP contact pigs. Under these study conditions, contact exposed pigs fed SDPP had delayed ASFV transmission and reduced virus load, likely by enhanced specific T-cell priming after the first ASFV-exposure. | ca |
dc.description.sponsorship | Funding for this study was provided by APC Europe, S.L.U., Granollers, Spain, and APC LLC, Ankeny, US. Both companies manufacture animal blood products for animal consumption. The companies provided support in the form of salaries for authors EB, JC, and J. Polo retrospectively, but none of these companies did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. We also acknowledge support of the Spanish Ministry of Science and Innovation (grant reference PID2019-107616RB-I00). | ca |
dc.format.extent | 15 | ca |
dc.language.iso | eng | ca |
dc.publisher | MDPI | ca |
dc.relation.ispartof | Vaccines | ca |
dc.rights | Attribution 4.0 International | ca |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.title | Feeding Spray-Dried Porcine Plasma to Pigs Reduces African Swine Fever Virus Load in Infected Pigs and Delays Virus Transmission—Study 1 | ca |
dc.type | info:eu-repo/semantics/article | ca |
dc.description.version | info:eu-repo/semantics/publishedVersion | ca |
dc.rights.accessLevel | info:eu-repo/semantics/openAccess | |
dc.embargo.terms | cap | ca |
dc.relation.projectID | MICIU/Programa Estatal de generación del conocimiento y fortalecimiento científico y tecnológico del sistema I+D+I y Programa Estatal de I+D+I orientada a los retos de la sociedad/PID2019-107616RB-I00/ES/Peste porcina africana; de la emergencia a evitar el endemismo/ | ca |
dc.subject.udc | 619 | ca |
dc.identifier.doi | https://doi.org/10.3390/vaccines11040824 | ca |
dc.contributor.group | Sanitat Animal | ca |
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