Diverse infectivity, transmissibility, and pathobiology of clade 2.3.4.4 H5Nx highly pathogenic avian influenza viruses in chickens
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Author
Kwon, Jung-Hoon
Lee, Dong-Hun
Criado, Miria Ferreira
Killmaster, Lindsay
Pantin-Jackwood, Mary J.
Swayne, David E.
Publication date
2023-06-12ISSN
2222-1751
Abstract
Clade 2.3.4.4 Eurasian lineage H5Nx highly pathogenic avian influenza virus (HPAIV) has become the globally dominant clade and caused global outbreaks since 2014. The clade 2.3.4.4 viruses have evolved into eight hemagglutinin subgroups (2.3.4.4a-h). In this study, we evaluated the infectivity, pathobiology, and transmissibility of seven clade 2.3.4.4 viruses (two 2.3.4.4a, two 2.3.4.4b, one 2.3.4.4c and two 2.3.4.4e) in chickens. The two clade 2.3.4.4e viruses caused 100% mortality and transmissibility in chickens. However, clade 2.3.4.4a and c viruses showed 80–90% mortality and 67% transmissibility. Clade 2.3.4.4b viruses showed 100% mortality, but no transmission to co-housed chickens was observed based on lack of seroconversion. All the infected chickens died showing systemic infection, irrespective of subgroup. The results highlight that all the clade 2.3.4.4 HPAIVs used in this study caused high mortality in infected chickens, but the transmissibility of the viruses in chickens was variable in contrast to that of previous Eurasian-lineage H5N1 HPAIVs. Changes in the pathogenicity and transmissibility of clade 2.3.4.4 HPAIVs warrant careful monitoring of the viruses to establish effective control strategies.
Document Type
Article
Document version
Published version
Language
English
Subject (CDU)
619 - Veterinary science
Pages
10
Publisher
Taylor and Francis Group
Is part of
Emerging Microbes and Infections
Citation
Kwon, Jung-Hoon, Kateri Bertran, Dong-Hun Lee, Miria Ferreira Criado, Lindsay Killmaster, Mary J. Pantin-Jackwood, and David E. Swayne. 2023. "Diverse infectivity, transmissibility, and pathobiology of clade 2.3.4.4 H5Nx highly pathogenic avian influenza viruses in chickens". Emerging Microbes and Infections 12:1, 2218945. doi: 10.1080/22221751.2023.2218945
Program
Sanitat Animal
This item appears in the following Collection(s)
- ARTICLES CIENTÍFICS [2555]
Rights
CC0 1.0 Universal
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Except where otherwise noted, this item's license is described as http://creativecommons.org/publicdomain/zero/1.0/