dc.contributor.author | Meléndez, Daniela M. | |
dc.contributor.author | Marti, Sonia | |
dc.contributor.author | Pajor, Edmond A. | |
dc.contributor.author | SidhuI, Pritam K. | |
dc.contributor.author | Gellatly, Désireé | |
dc.contributor.author | Moya, Diego | |
dc.contributor.author | Janzen, Eugene D. | |
dc.contributor.author | Coetzee, Johann F. | |
dc.contributor.author | Schwartzkopf-Genswein, Karen S. | |
dc.contributor.other | Producció Animal | ca |
dc.date.accessioned | 2019-04-03T12:55:20Z | |
dc.date.available | 2019-04-03T12:55:20Z | |
dc.date.issued | 2018-11-30 | |
dc.identifier.citation | Meléndez, Daniela M., Sonia Marti, Edmond A. Pajor, Pritam K. Sidhu, Désirée Gellatly, Diego Moya, Eugene D. Janzen, Johann F. Coetzee, and Karen S. Schwartzkopf-Genswein. 2018. "Effect Of Meloxicam And Lidocaine Administered Alone Or In Combination On Indicators Of Pain And Distress During And After Knife Castration In Weaned Beef Calves". PLOS ONE 13 (11): e0207289. Public Library of Science (PLoS). doi:10.1371/journal.pone.0207289./journal.pone.0207289. | ca |
dc.identifier.issn | 1932-6203 | ca |
dc.identifier.uri | http://hdl.handle.net/20.500.12327/242 | |
dc.description.abstract | To assess the effect of meloxicam and lidocaine on indicators of pain associated with castration, forty-eight Angus crossbred beef calves (304 ± 40.5 kg of BW, 7–8 months of age) were used in a 28 day experiment. The experiment consisted of a 2 × 2 factorial design where main factors included provision of analgesia and local anaesthesia. Analgesia consisted of: no-meloxicam (N; n = 24) single s.c. administration of lactated ringer’s solution and meloxicam (M; n = 24) single dose of 0.5 mg/kg of s.c. meloxicam. Local anesthesia consisted of: no-lidocaine (R; n = 24) ring block administration of lactated ringer’s solution or lidociane (L; n = 24) ring block administration of lidocaine. To yield the following treatments: no meloxicam + no lidocaine (N-R; n = 12), no meloxicam + lidocaine (N-L; n = 12), meloxicam + no lidocaine (M-R; n = 12) and meloxicam + lidocaine (M-L; n = 12). Salivary cortisol concentrations were lower (lidocaine × time effect; P < 0.01) in L calves than R calves 0.5 and 1 hours after castration, while concentrations were lower (meloxicam × time effect; P = 0.02) in M calves than N calves at 2, 4 and 48 hours. The serum amyloid-A concentrations were greater (lidocaine × time effect; P < 0.01) in R calves than L calves on days 1, 3, 21 and 28 after castration. Haptoglobin concentrations were greater (meloxicam × time effect; P = 0.01) in N calves than M calves 24 and 48 hours after castration. Lower (lidocaine effect; P < 0.01) visual analog scale (VAS) scores, leg movement frequencies and head movement distance were observed in L calves than R calves at the time of castration. Escape behaviour during castration was lower (lidocaine effect; P < 0.05) in L calves than R calves based on data captured with accelerometer and head gate devices. Scrotal circumference had a triple interaction (lidocaine × meloxicam × time; P = 0.03), where M-R calves had greater scrotal circumference than M-L calves 28 d after castration, but no differences were observed between both groups and N-R and N-L calves. No differences (P > 0.05) were observed for average daily gain (ADG), weights or feeding behaviour. Overall, both lidocaine and meloxicam reduced physiological and behavioural indicators of pain. Although there was only one meloxicam × lidocaine interaction, lidocaine and meloxicam reduced physiological and behavioural parameters at different time points, which could be more effective at mitigating pain than either drug on its own. | ca |
dc.format.extent | 21 | ca |
dc.language.iso | eng | ca |
dc.publisher | Public Library of Science | ca |
dc.relation.ispartof | PLoS ONE | ca |
dc.rights | Attribution 4.0 International | ca |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.title | Effect of meloxicam and lidocaine administered alone or in combination on indicators of pain and distress during and after knife castration in weaned beef calves | ca |
dc.type | info:eu-repo/semantics/article | ca |
dc.description.version | info:eu-repo/semantics/publishedVersion | ca |
dc.rights.accessLevel | info:eu-repo/semantics/openAccess | |
dc.embargo.terms | cap | ca |
dc.identifier.doi | https://doi.org/10.1371/journal.pone.0207289 | ca |
dc.contributor.group | Producció de Remugants | ca |