Advances and gaps in SARS-CoV-2 infection models
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Author
Muñoz-Fontela, César
Widerspick, Lina
Albrecht, Randy A.
Beer, Martin
Carroll, Miles W.
de Wit, Emmie
Diamond, Diamond
Dowling, William E.
Funnell, Simon G. P.
García-Sastre, Adolfo
Gerhards, Nora M.
de Jong, Rineke
Munster, Vincent J.
Neyts, Johan
Perlman, Stanley
Reed, Douglas S.
Richt, Juergen A.
Riveros-Balta, Ximena
Roy, Chad J.
Salguero, Francisco J.
Schotsaert, Michael
Schwartz, Lauren M.
Seder, Robert A.
Vasan, Seshadri S.
Henao-Restrepo, Ana María
Barouch, Dan H.
Publication date
2022-01-13ISSN
1553-7366
Abstract
AU The:global Pleaseco response nfirmthata tollhe Coronavirus adinglevelsa Disease rerepres 2019 entedcor (COVID-19) rectly: is now facing new challenges such as vaccine inequity and the emergence of SARS-CoV-2 variants of concern
(VOCs). Preclinical models of disease, in particular animal models, are essential to investigate VOC pathogenesis, vaccine correlates of protection and postexposure therapies.
Here, we provide an update from the World Health Organization (WHO) COVID-19 modeling expert group (WHO-COM) assembled by WHO, regarding advances in preclinical models. In particular, we discuss how animal model research is playing a key role to evaluate
VOC virulence, transmission and immune escape, and how animal models are being refined
to recapitulate COVID-19 demographic variables such as comorbidities and age.
Document Type
Article
Document version
Published version
Language
English
Subject (CDU)
619 - Veterinary science
Pages
15
Publisher
Public Library of Science
Is part of
PLoS Pathogens
Citation
Muñoz-Fontela, César, Lina Widerspick, Randy A. Albrecht, Martin Beer, Miles W. Carroll, Emmie De Wit, Michael S. Diamond, et al. 2022.“Advances and Gaps in SARS-CoV-2 Infection Models.” PLOS Pathogens 18(1): e1010161. doi:10.1371/journal.ppat.1010161.
Program
Sanitat Animal
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- ARTICLES CIENTÍFICS [2555]
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