Intensive antibiotic treatment of sows with parenteral crystalline ceftiofur and tulathromycin alters the composition of the nasal microbiota of their ofspring
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Author
Huerta, Eva
Aragon, Virginia
Publication date
2023-11-24ISSN
0928-4249
Abstract
The nasal microbiota plays an important role in animal health and the use of antibiotics is a major factor that infu‑
ences its composition. Here, we studied the consequences of an intensive antibiotic treatment, applied to sows
and/or their ofspring, on the piglets’ nasal microbiota. Four pregnant sows were treated with crystalline ceftiofur
and tulathromycin (CTsows) while two other sows received only crystalline ceftiofur (Csows). Sow treatments were
performed at D‑4 (four days pre‑farrowing), D3, D10 and D17 for ceftiofur and D‑3, D4 and D11 for tulathromycin.
Half of the piglets born to CTsows were treated at D1 with ceftiofur. Nasal swabs were taken from piglets at 22–24 days
of age and bacterial load and nasal microbiota composition were defned by 16 s rRNA gene qPCR and amplicon
sequencing. Antibiotic treatment of sows reduced their nasal bacterial load, as well as in their ofspring, indicating
a reduced bacterial transmission from the dams. In addition, nasal microbiota composition of the piglets exhibited
signs of dysbiosis, showing unusual taxa. The addition of tulathromycin to the ceftiofur treatment seemed to enhance
the deleterious efect on the microbiota diversity by diminishing some bacteria commonly found in the piglets’ nasal
cavity, such as Glaesserella, Streptococcus, Prevotella, Staphylococcus and several members of the Ruminococcaceae
and Lachnospiraceae families. On the other hand, the additional treatment of piglets with ceftiofur resulted in no fur‑
ther efect beyond the treatment of the sows. Altogether, these results suggest that intensive antibiotic treatments
of sows, especially the double antibiotic treatment, disrupt the nasal microbiota of their ofspring and highlight
the importance of sow‑to‑piglet microbiota transmission.
Document Type
Article
Document version
Published version
Language
English
Subject (CDU)
619 - Veterinary science
Pages
12
Publisher
BMC
Is part of
Veterinary Research
Citation
Bonillo-Lopez, Laura, Pau Obregon-Gutierrez, Eva Huerta, Florencia Correa‐Fiz, Marina Sibila, and Virginia Aragón. 2023. “Intensive antibiotic treatment of sows with parenteral crystalline ceftiofur and tulathromycin alters the composition of the nasal microbiota of their offspring”. Veterinary Research 54 (1): 112. doi:10.1186/s13567-023-01237-y.
Grant agreement number
MICIU/Programa Estatal de generación del conocimiento y fortalecimiento científico y tecnológico del sistema I+D+I y Programa Estatal de I+D+I orientada a los retos de la sociedad/PID2019-106233RB-I00/ES/FUNCIONALIDAD Y EFECTO DE LA MICROBIOTA NASAL SOBRE LA RESPUESTA INMUNE DE LOS LECHONES/
Program
Sanitat Animal
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- ARTICLES CIENTÍFICS [2635]
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