The Susceptibility Trends of Respiratory and Enteric Porcine Pathogens to Last-Resource Antimicrobials
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Author
Vilaró, Anna
Novell, Elena
Enrique-Tarancon, Vicens
Baliellas, Jordi
Fraile, Lorenzo
Publication date
2023-10-28ISSN
2079-6382
Abstract
Monitoring the antimicrobial susceptibility of last-resource antimicrobials for veterinary
pathogens is urgently needed from a one-health perspective. The objective of this study was to analyze
the antimicrobial susceptibility trends of Spanish porcine bacteria to quinolones, cephalosporins, and
polymyxins. Isolates of Actinobacillus pleuropneumoniae, Pasteurella multocida, and Escherichia coli were
isolated from sick pigs from 2019 to 2022. An antimicrobial susceptibility test was determined based
on the minimal inhibitory concentration (MIC) following an internationally accepted methodology.
The MIC categorization was based on distributing the range of MIC values in four categories, with
category one being the most susceptible (lowest MIC value) and category four the least susceptible
(highest MIC value). Moreover, clinical susceptibility (susceptible/non-susceptible) was also determined according to the CLSI and EUCAST clinical breakpoints. A logistic and multinomial logistic
regression model was used to analyze the susceptibility data for dichotomized and categorized MIC
data, respectively, for any pair of antimicrobial/microorganism. In general terms, the antimicrobial
susceptibility of pig bacteria to these antimicrobials remained stable or increased in the last four
years in Spain. In the case of A. pleuropneumoniae and quinolones, a significant temporal trend was
observed where isolates from 2020 had significantly increased odds of being more susceptible than
isolates from 2019. In the case of E. coli and polymyxins, a significant temporal trend was observed
where isolates from 2020 and 2021 had significantly increased odds of being more susceptible than
isolates from 2019 and 2020, respectively. Finally, significant odds of being less susceptible were only
observed for cephalosporins and E. coli for 2020 versus 2019, stagnating for the rest of study period.
These results provide sound data on critically important antimicrobials in swine medicine.
Document Type
Article
Document version
Published version
Language
English
Subject (CDU)
619 - Veterinary science
Pages
19
Publisher
MDPI
Is part of
Antibiotics
Citation
Vilaró, Anna, Elena Novell, Vicens Enrique-Tarancón, Jordi Baliellas, Lourdes Migura-García, and Lorenzo Fraile. 2023. “The Susceptibility Trends of Respiratory and Enteric Porcine Pathogens to Last-Resource Antimicrobials.” Antibiotics 12 (11): 1575. https://doi.org/10.3390/antibiotics12111575.
Program
Sanitat Animal
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- ARTICLES CIENTÍFICS [2555]
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