Interrelation between gut microbiota, SCFA, and fatty acid composition in pigs
Author
Sebastià, Cristina
Folch, Josep M.
Estellé, Jordi
Passols, Magí
Muñoz, María
García-Casco, Juan M.
Fernández, Ana I.
Castelló, Anna
Sánchez, Armand
Publication date
2023-12-14ISSN
2379-5077
Abstract
The gut microbiota is a key player in the host metabolism. Some bacteria are able to ferment non-digestible compounds and produce short-chain fatty acids that the host can later transform and accumulate in tissue. In this study, we aimed to better understand the relationships between the microorganisms and the short-chain fatty acid composition of the rectal content, including the possible linkage with the fatty acid composition in backfat and muscle of the pig. We studied a Duroc × Iberian crossbred population, and we found significant correlations between different bacterial and archaeal genera and the fatty acid profile. The abundance of n-butyric acid in the rectal content was positively associated with Prevotella spp. and negatively associated with Akkermansia spp., while conversely, the abundance of acetic acid was negatively and positively associated with the levels of Prevotella spp. and Akkermansia spp., respectively. The most abundant genus, Rikenellaceae RC9 gut group, had a positive correlation with palmitic acid in muscle and negative correlations with stearic acid in backfat and oleic acid in muscle. These results suggest the possible role of Prevotella spp. and Akkermansia spp. as biomarkers for acetic and n-butyric acids, and the relationship of Rikenellaceae RC9 gut group with the lipid metabolism, building up the potential, although indirect, role of the microbiota in the modification of the backfat and muscle fatty acid composition of the host.
Document Type
Article
Document version
Published version
Language
English
Subject (CDU)
636 - Animal husbandry and breeding in general. Livestock rearing. Breeding of domestic animals
Pages
19
Publisher
American Society for Microbiology
Is part of
mSystems
Citation
Sebastià, Cristina, Josep M. Folch, Maria Ballester, Jordi Estellé, Magí Passols, María Muñoz, Juan M. García-Casco, et al. 2024. "Interrelation between gut microbiota, SCFA, and fatty acid composition in pigs". mSystems 9 (1). doi:10.1128/msystems.01049-23.
Grant agreement number
MINECO/Programa Estatal de I+D+I orientada a los retos de la sociedad/AGL2017-82641-R/ES/GENOMICA FUNCIONAL, BIOLOGIA DE SISTEMAS Y MICROBIOMICA APLICADAS A LA IDENTIFICACION DE REGULADORES GENETICOS DEL CRECIMIENTO, ENGRASAMIENTO Y CALIDAD DE LA CARNE EN PORCINO/
MICINN/Programa Estatal de generación del conocimiento y fortalecimiento científico y tecnológico del sistema I+D+I y Programa Estatal de I+D+I orientada a los retos de la sociedad/PID2020-112677RB-C22/ES/FISIOLOGIA MOLECULAR DEL METABOLISMO ENERGETICO EN PORCINO: BASES PARA LA SELECCION DE LA EFICIENCIA PRODUCTIVA Y CALIDAD DE CARNE/
MINECO/Programa Estatal de fomento de la investigación científica y técnica de excelencia/SEV-2015-0533/ES/ /
MICIU/Programa Estatal de generación del conocimiento y fortalecimiento científico y tecnológico del sistema I+D+I/CEX2019-000902-S/ES/ /
FEDER/ / /EU/ /
Program
Genètica i Millora Animal
This item appears in the following Collection(s)
- ARTICLES CIENTÍFICS [2555]
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