Middle East respiratory coronavirus (MERS-CoV) internalized by llama alveolar macrophages does not result in virus replication or induction of pro-inflammatory cytokines
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Author
Sachse, Martin
Te, Nigeer
Risco, Cristina
Vergara-Alert, Júlia
Publication date
2024-03ISSN
1286-4579
Abstract
Severe Middle East respiratory syndrome (MERS) is characterized by massive infiltration of immune cells
in lungs. MERS-coronavirus (MERS-CoV) replicates in vitro in human macrophages, inducing high proinflammatory responses. In contrast, camelids, the main reservoir for MERS-CoV, are asymptomatic
carriers. Although limited infiltration of leukocytes has been observed in the lower respiratory tract of
camelids, their role during infection remains unknown. Here we studied whether llama alveolar macrophages (LAMs) are susceptible to MERS-CoV infection and can elicit pro-inflammatory responses.
MERS-CoV did not replicate in LAMs; however, they effectively capture and degrade viral particles.
Moreover, transcriptomic analyses showed that LAMs do not induce pro-inflammatory cytokines upon
MERS-CoV sensing.
Document Type
Article
Document version
Published version
Language
English
Subject (CDU)
619 - Veterinary science
Pages
6
Publisher
Elsevier
Is part of
Microbes and Infection
Citation
Rodón, Jordi, Martin Sachse, Nigeer Te, Joaquím Segalés, Albert Bensaid, Cristina Risco, and Júlia Vergara‐Alert. 2023. “Middle East Respiratory Coronavirus (MERS-CoV) Internalized by Llama Alveolar Macrophages Does Not Result in Virus Replication or Induction of Pro-inflammatory Cytokines.” Microbes and Infection, 26 (3): 105252. doi:10.1016/j.micinf.2023.105252.
Grant agreement number
EC/PF7/115760/EU/Zoonotic Anticipation and Preparedness Initiative/ZAPI
EC/H2020/731014/EU/Veterinary Biocontained facility Network for excellence in animal infectiology research and experimentation/VetBioNet
MICIU/Programa Estatal de I+D+I orientada a los retos de la sociedad/RTI2018-094445-B-I00/ES/BUSQUEDA DE NUEVOS ANTIVIRALES DE AMPLIO ESPECTRO: TRANSPORTE DE LIPIDOS Y PROTEINAS MITOCONDRIALES COMO DIANAS/
Program
Sanitat Animal
This item appears in the following Collection(s)
- ARTICLES CIENTÍFICS [2845]
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc-nd/4.0/