Distribution patterns of influenza virus receptors and viral attachment patterns in the respiratory and intestinal tracts of seven avian species
View/Open
Author
Costa, Taiana
Chaves, Aida J
Valle, Rosa
van Riel, Debby
Kuiken, Thijs
Majó, Natàlia
Ramis, Antonio
Publication date
2012-04-10ISSN
0928-4249
Abstract
This study assessed the presence of sialic acid α-2,3 and α-2,6 linked glycan receptors in seven avian species. The
respiratory and intestinal tracts of the chicken, common quail, red-legged partridge, turkey, golden pheasant,
ostrich, and mallard were tested by means of lectin histochemistry, using the lectins Maackia amurensis agglutinin
II and Sambucus nigra agglutinin, which show affinity for α-2,3 and α-2,6 receptors, respectively. Additionally, the
pattern of virus attachment (PVA) was evaluated with virus histochemistry, using an avian-origin H4N5 virus and a
human-origin seasonal H1N1 virus. There was a great variation of receptor distribution among the tissues and
avian species studied. Both α-2,3 and α-2,6 receptors were present in the respiratory and intestinal tracts of the
chicken, common quail, red-legged partridge, turkey, and golden pheasant. In ostriches, the expression of the
receptor was basically restricted to α-2,3 in both the respiratory and intestinal tracts and in mallards the α-2,6
receptors were absent from the intestinal tract. The results obtained with the lectin histochemistry were, in general,
in agreement with the PVA. The differential expression and distribution of α-2,3 and α-2,6 receptors among various
avian species might reflect a potentially decisive factor in the emergence of new viral strains.
Document Type
Article
Document version
Published version
Language
English
Subject (CDU)
619 - Veterinary science
Pages
13
Publisher
BMC
Is part of
Veterinary Research
Citation
Costa, Teresa, Andrea Chaves, Rosa Valle, Ayub Darji, Debby Van Riel, Thijs Kuiken, Natàlia Majó, and Antonio Ramis. 2012. “Distribution Patterns of Influenza Virus Receptors and Viral Attachment Patterns in the Respiratory and Intestinal Tracts of Seven Avian Species.” Veterinary Research 43 (1): 28. doi:10.1186/1297-9716-43-28.
Grant agreement number
EC/FP6/44098/EU/Molecular factors and mechanisms of transmission and pathogenicity of highly pathogenic Avian Influenza Virus/EUROFLU
MICINN/Programa Nacional de Proyectos de Investigación Fundamental/RTA2011-00111-C03-01/ES/Dinámica viral en diferentes especies aviares: mecanismos moleculares de transmisión y patogenicidad/
Program
Sanitat Animal
This item appears in the following Collection(s)
- ARTICLES CIENTÍFICS [2555]
The following license files are associated with this item:
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/