Pharmaceuticals and endocrine disruptors in raw and cooked seafood from European market: Concentrations and human exposure levels
Author
Álvarez-Muñoz, Diana
Rodríguez-Mozaz, Sara
Jacobs, Silke
Serra-Compte, Albert
Cáceres, Nuria
Sioen, Isabelle
Verbeke, Wim
Barbosa, Vera
Ferrari, Federico
Cunha, Sara
Granby, Kit
Robbens, Johan
Kotterman, Michiel
Marques, Antonio
Barceló, Damià
Publication date
2018-08-30ISSN
0160-4120
Abstract
Pharmaceuticals (PhACs) and endocrine disrupting compounds (EDCs) are chemicals of emerging concern that can accumulate in seafood sold in markets. These compounds may represent a risk to consumers through effects on the human reproductive system, metabolic disorders, pathogenesis of breast cancer or development of microbial resistance. Measuring their levels in highly consumed seafood is important to assess the potential risks to human health. Besides, the effect of cooking on contaminant levels is relevant to investigate. Therefore, the objectives of this research were to study the presence and levels of PhACs and EDCs in commercially available seafood in the European Union market, to investigate the effect of cooking on contaminant levels, and to evaluate the dietary exposure of humans to these compounds through seafood consumption. A sampling survey of seafood from 11 European countries was undertaken. Twelve highly consumed seafood types were analysed raw and cooked with 3 analytical methods (65 samples, 195 analysis). PhACs were mostly not detectable or below quantification limits in seafood whereas EDCs were a recurrent group of contaminants quantified in the majority of the samples. Besides, cooking by steaming significantly increased their levels in seafood from 2 to 46-fold increase. Based on occurrence and levels, bisphenol A, methylparaben and triclosan were selected for performing a human exposure assessment and health risk characterisation through seafood consumption. The results indicate that the Spanish population has the highest exposure to the selected EDCs through seafood consumption, although the exposure via seafood remained below the current toxicological reference values.
Document Type
Article
Document version
Accepted version
Language
English
Subject (CDU)
663/664 - Food and nutrition. Enology. Oils. Fat
Pages
36
Publisher
Elsevier
Is part of
Environmental International
Citation
Álvarez-Muñoz, Diana, Sara Rodríguez-Mozaz, Silke Jacobs, Albert Serra-Compte, Nuria Cáceres, Isabelle Sioen, and Wim Verbeke et al. 2018. "Pharmaceuticals And Endocrine Disruptors In Raw And Cooked Seafood From European Market: Concentrations And Human Exposure Levels". Environment International 119: 570-581. Elsevier BV. doi:10.1016/j.envint.2018.07.006.
Grant agreement number
EC/FP7/311820/EU/Priority environmental contaminants in seafood: safety assessment, impact and public perception/ECSAFESEAFOOD
MINECO/ /RYC2014-16707/ES/ /
MINECO/Programa Estatal de I+D+I orientada a los retos de la sociedad/CTM2015-73179-JIN/ES/IDENTIFICACION DE XENOBIOTICOS BIOACUMULABLES EN MEJILLON SIGUIENDO UN ENFOQUE METABOLOMICO: EXPOSICION HUMANA Y AMBIENTAL/XENOMETABOLOMIC
MINECO-FEDER/Programa Estatal de I+D+I orientada a los retos de la sociedad/CTM2015-73179-JIN/ES/Identificación de xenobioticos bioacumulables en mejillón siguiendo un enfoque metabolomico: exposición humana y ambiental/XENOMETABOLOMIC
Program
Aigües Marines i Continentals
This item appears in the following Collection(s)
- ARTICLES CIENTÍFICS [2850]
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc-nd/4.0/