Elucidating the Onset of Cross-Protective Immunity after Intranasal Vaccination with the Attenuated African Swine Fever Vaccine Candidate BA71ΔCD2
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Author
Tort-Miró, Aida
Navas, María Jesús
Muñoz, Marta
Martín-Mur, Beatriz
Meas, Sochanwattey
Motuzova, Veronika
Chang, Chia-Yu
Gut, Marta
Esteve-Codina, Anna
Gavrilov, Boris
Liu, Lihong
Publication date
2024-05-09ISSN
2076-393X
Abstract
African swine fever (ASF) is a deadly disease of swine currently causing a worldwide
pandemic, leading to severe economic consequences for the porcine industry. The control of disease
spread is hampered by the limitation of available effective vaccines. Live attenuated vaccines (LAVs)
are currently the most advanced vaccine prototypes, providing strong protection against ASF. However, the significant advances achieved using LAVs must be complemented with further studies to
analyze vaccine-induced immunity. Here, we characterized the onset of cross-protective immunity
triggered by the LAV candidate BA71ΔCD2. Intranasally vaccinated pigs were challenged with the
virulent Georgia 2007/1 strain at days 3, 7 and 12 postvaccination. Only the animals vaccinated 12
days before the challenge had effectively controlled infection progression, showing low virus loads,
minor clinical signs and a lack of the unbalanced inflammatory response characteristic of severe
disease. Contrarily, the animals vaccinated 3 or 7 days before the challenge just showed a minor
delay in disease progression. An analysis of the humoral response and whole blood transcriptome
signatures demonstrated that the control of infection was associated with the presence of virusspecific IgG and a cytotoxic response before the challenge. These results contribute to our understanding of protective immunity induced by LAV-based vaccines, encouraging their use in emergency responses in ASF-affected areas.
Document Type
Article
Document version
Published version
Language
English
Subject (CDU)
619 - Veterinary science
Pages
21
Publisher
MDPI
Is part of
Vaccines
Citation
Marín-Moraleda, David, Jordana Muñoz-Basagoiti, Aida Tort-Miró, María Jesús Navas, Marta Muñoz, Enric Vidal, Àlex Cobos, et al. 2024. “Elucidating the Onset of Cross-Protective Immunity after Intranasal Vaccination with the Attenuated African Swine Fever Vaccine Candidate BA71ΔCD2”. Vaccines 12 (5): 517. doi: 10.3390/vaccines12050517
Grant agreement number
MICINN/Programa Estatal para Impulsar la Investigación Científico-Técnica y su Transferencia/PID2022-136312OB-I00/ES/ /
Program
Sanitat Animal
This item appears in the following Collection(s)
- ARTICLES CIENTÍFICS [2838]
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/