Cytokine profiles and phenotype regulation of antigen presenting cells by genotype-I porcine reproductive and respiratory syndrome virus isolates
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Author
Gimeno, Mariona
Darwich, Laila
Diaz, Ivan
de la Torre, Eugenia
Martín, Marga
Inumaru, Shigeki
Cano, Esmeralda
Domingo, Mariano
Mateu, Enric
Publication date
2011-01-18ISSN
0928-4249
Abstract
The present study examined the immunological response of antigen presenting cells (APC) to genotype-I isolates
of porcine reproductive and respiratory syndrome virus (PRRSV) infection by analysing the cytokine profile induced
and evaluating the changes taking place upon infection on immunologically relevant cell markers (MHCI, MHCII,
CD80/86, CD14, CD16, CD163, CD172a, SWC9). Several types of APC were infected with 39 PRRSV isolates. The
results show that different isolates were able to induce different patterns of IL-10 and TNF-a. The four possible
phenotypes based on the ability to induce IL-10 and/or TNF-α were observed, although different cell types
seemed to have different capabilities. In addition, isolates inducing different cytokine-release profiles on APC could
induce different expression of cell markers.
Document Type
Article
Document version
Published version
Language
English
Subject (CDU)
619 - Veterinary science
Pages
10
Publisher
BMC
Is part of
Veterinary Research
Citation
Gimeno, Mariona, Laila Darwich, Ivan Diaz, Eugenia De La Torre, Joan Pujols, Marga Martín, Shigeki Inumaru, et al. 2011. “Cytokine Profiles and Phenotype Regulation of Antigen Presenting Cells by genotype-I Porcine Reproductive and Respiratory Syndrome Virus Isolates.” Veterinary Research 42 (1): 9. doi: 10.1186/1297-9716-42-9
Grant agreement number
MEC/ /AGL2005-07073-C02-02/ES/ Nuevas estrategias de inmunización frente al virus del síndrome reproductivo y respiratorio porcino (PRRS): Estudios inmunológicos y eficacia de antígenos fusionados a quimioquinas/GAN
MEC/ /AGL2006-13809-C03-01/ES/Nuevas estrategias vacunales e inmunomoduladores basadas en la estimulación de las células dendríticas porcinas empleando como modelo el virus de la gripe/GAN
MICINN/Programa Nacional de Proyectos de Investigación Fundamental/AGL2008-05708-C02-02/ES/CARACTERIZACION ANTIGENICA DE CEPAS DEL VIRUS DEL SINDROME REPRODUCTOR Y RESPIRATORIO PORCINO DE DISTINTO ORIGEN Y SU RELEVANCIA PARA EL DESARROLLO DE VACUNAS EFICACES/GAN
MEC/ /CSD2006-00007/ES/Patogenia de infecciones víricas del cerdo/PORCIVIR
Program
Sanitat Animal
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