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dc.contributor.authorBertran, Kateri
dc.contributor.authorPérez-Ramírez, Elisa
dc.contributor.authorBusquets, Núria
dc.contributor.authorDolz, Roser
dc.contributor.authorRamis, Antonio
dc.contributor.authorDarji, Ayub
dc.contributor.authorAbad, Francesc Xavier
dc.contributor.authorValle, Rosa
dc.contributor.authorChaves, Aida
dc.contributor.authorVergara-Alert, Júlia
dc.contributor.authorBarral, Marta
dc.contributor.authorHöfle, Ursula
dc.contributor.authorMajó, Natàlia
dc.contributor.otherProducció Animalca
dc.date.accessioned2024-05-17T11:39:11Z
dc.date.available2024-05-17T11:39:11Z
dc.date.issued2011-02-07
dc.identifier.citationBertran, Kateri, Elisa Pérez-Ramírez, Núria Busquets, Roser Dolz, Antonio Ramis, Ayub Darji, Francesc Xavier Abad, et al. 2011. “Pathogenesis and Transmissibility of Highly (H7N1) and Low (H7N9) Pathogenic Avian Influenza Virus Infection in Red-legged Partridge (Alectoris Rufa).” Veterinary Research 42 (1): 24. doi: 10.1186/1297-9716-42-24ca
dc.identifier.issn0928-4249ca
dc.identifier.urihttp://hdl.handle.net/20.500.12327/2999
dc.description.abstractAn experimental infection with highly pathogenic avian influenza virus (HPAIV) and low pathogenic avian influenza virus (LPAIV) was carried out in red-legged partridges (Alectoris rufa) in order to study clinical signs, gross and microscopic lesions, and viral distribution in tissues and viral shedding. Birds were infected with a HPAIV subtype H7N1 (A/Chicken/Italy/5093/1999) and a LPAIV subtype H7N9 (A/Anas crecca/Spain/1460/2008). Uninoculated birds were included as contacts in both groups. In HPAIV infected birds, the first clinical signs were observed at 3 dpi, and mortality started at 4 dpi, reaching 100% at 8 dpi. The presence of viral antigen in tissues and viral shedding were confirmed by immunohistochemistry and quantitative real time RT-PCR (qRRT-PCR), respectively, in all birds infected with HPAIV. However, neither clinical signs nor histopathological findings were observed in LPAIV infected partridges. In addition, only short-term viral shedding together with seroconversion was detected in some LPAIV inoculated animals. The present study demonstrates that the red-legged partridge is highly susceptible to the H7N1 HPAIV strain, causing severe disease, mortality and abundant viral shedding and thus contributing to the spread of a potential local outbreak of this virus. In contrast, our results concerning H7N9 LPAIV suggest that the red-legged partridge is not a reservoir species for this virus.ca
dc.description.sponsorshipThis work was partially funded by the coordinated project FAU2006-00019- C03-00 of the Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA) and the Ministry of Education and Science of Spain. E. Pérez-Ramírez currently has an I3p fellowship from the Spanish Science Council (CSIC), and K. Bertran has an FPU Pre-Doctoral grant from the Ministry of Education of Spain. We are grateful to the personnel of “El Bonillo” farm who kindly provided the animals used in the study. We also thank the personnel of the experimental farm of IREC “Dehesa de Galiana” for their collaboration in bird maintenance, and the personnel of the BSL-3 of CReSA for their excellent technical assistance.ca
dc.format.extent9ca
dc.language.isoengca
dc.publisherBMCca
dc.relation.ispartofVeterinary Researchca
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titlePathogenesis and transmissibility of highly (H7N1) and low (H7N9) pathogenic avian influenza virus infection in red-legged partridge (Alectoris rufa)ca
dc.typeinfo:eu-repo/semantics/articleca
dc.description.versioninfo:eu-repo/semantics/publishedVersionca
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.termscapca
dc.relation.projectIDINIA/Programa nacional de recursos y tecnologías agroalimentarias/FAU2006-00019-C03-01/ES/Ensayos de persistencia ambiental del virus y estudio de la inmunopatogenia en aves criadas en regímenes no intensivos/ca
dc.subject.udc619ca
dc.identifier.doihttps://doi.org/10.1186/1297-9716-42-24ca
dc.contributor.groupSanitat Animalca


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