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Exploring the Antiviral Potential of Natural Compounds against Influenza: A Combined Computational and Experimental Approach
dc.contributor.author | Perovic, Vladimir | |
dc.contributor.author | Stevanovic, Kristina | |
dc.contributor.author | Bukreyeva, Natalya | |
dc.contributor.author | Paessler, Slobodan | |
dc.contributor.author | Maruyama, Junki | |
dc.contributor.author | López-Serrano, Sergi | |
dc.contributor.author | Darji, Ayub | |
dc.contributor.author | Sencanski, Milan | |
dc.contributor.author | Radosevic, Draginja | |
dc.contributor.author | Berardozzi, Simone | |
dc.contributor.author | Botta, Bruno | |
dc.contributor.author | Mori, Mattia | |
dc.contributor.author | Glisic, Sanja | |
dc.contributor.other | Producció Animal | ca |
dc.date.accessioned | 2024-06-14T07:51:10Z | |
dc.date.available | 2024-06-14T07:51:10Z | |
dc.date.issued | 2024-04-30 | |
dc.identifier.citation | Perovic, Vladimir, Kristina Stevanovic, Natalya Bukreyeva, Slobodan Paessler, Junki Maruyama, Sergi López-Serrano, Ayub Darji, et al. 2024. “Exploring the Antiviral Potential of Natural Compounds Against Influenza: A Combined Computational and Experimental Approach.” International Journal of Molecular Sciences 25 (9): 4911. https://doi.org/10.3390/ijms25094911. | ca |
dc.identifier.issn | 1661-6596 | ca |
dc.identifier.uri | http://hdl.handle.net/20.500.12327/3048 | |
dc.description.abstract | The influenza A virus nonstructural protein 1 (NS1), which is crucial for viral replication and immune evasion, has been identified as a significant drug target with substantial potential to contribute to the fight against influenza. The emergence of drug-resistant influenza A virus strains highlights the urgent need for novel therapeutics. This study proposes a combined theoretical criterion for the virtual screening of molecular libraries to identify candidate NS1 inhibitors. By applying the criterion to the ZINC Natural Product database, followed by ligand-based virtual screening and molecular docking, we proposed the most promising candidate as a potential NS1 inhibitor. Subsequently, the selected natural compound was experimentally evaluated, revealing measurable virus replication inhibition activity in cell culture. This approach offers a promising avenue for developing novel anti-influenza agents targeting the NS1 protein. | ca |
dc.description.sponsorship | This research was funded by Ministry of Science, Technological Development and Innovation of the Republic of Serbia, grant number 451-03-66/2024-03/200017. | ca |
dc.format.extent | 15 | ca |
dc.language.iso | eng | ca |
dc.publisher | MDPI | ca |
dc.relation.ispartof | International Journal of Molecular Sciences | ca |
dc.rights | Attribution 4.0 International | ca |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.title | Exploring the Antiviral Potential of Natural Compounds against Influenza: A Combined Computational and Experimental Approach | ca |
dc.type | info:eu-repo/semantics/article | ca |
dc.description.version | info:eu-repo/semantics/publishedVersion | ca |
dc.rights.accessLevel | info:eu-repo/semantics/openAccess | |
dc.embargo.terms | cap | ca |
dc.subject.udc | 619 | ca |
dc.identifier.doi | https://doi.org/10.3390/ijms25094911 | ca |
dc.contributor.group | Sanitat Animal | ca |
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