Comparison of vaccination protocols against Mycoplasma hyopneumoniae during the gilt acclimation period
Autor/a
Garza-Moreno, Laura
Pieters, Maria
López-Soria, Sergio
Carmona, Marta
Krejci, Roman
Fecha de publicación
2018-12-12ISSN
0378-1135
Resumen
This study evaluated different gilt vaccination protocols againstMycoplasma (M.) hyopneumoniaeat acclimationand their effect on the genetic diversity. A total of 180M. hyopneumoniaenaïve gilts were selected 1 week post-entry (wpe) at the acclimation barn in a clinically affectedM. hyopneumoniaefarm. Gilts were distributed ac-cording to theM. hyopneumoniaeantibodies levels into three different vaccination schedules: A) four doses of aM. hyopneumoniaecommercial vaccine at 2, 4, 6 and 8 wpe; B) two vaccine doses at 2 and 6 wpe and PBS at 4 and8 wpe; and C) four PBS doses at the same wpe. Detection ofM. hyopneumoniae(rt-PCR) and antibodies (ELISA)were assessed in gilts at 1, 14, 27 and 34 wpe and in 6 of their piglets at weaning. Rt-PCR positive gilts weredetected at 14 wpe, being the proportion significantly lower in groups A and B (3/120, 3%) than C (27/60, 45%).Seroconversion was detected at 14 wpe, showing significant differences in percentage of inhibition (PI) betweengroups A (median 4.9, range 3.1–19.9) and B (5.5, 3.7–13.5), and C (14.3, 3.3–53.2). Gilts remained seropositiveover the study and significant differences in PI were detected between groups A and B versus C. All piglets werert-PCR negative, but the proportion of seropositive piglets coming from vaccinated gilts was significantly higherthan the non-vaccinated group.M. hyopneumoniaecharacterization showed high variability. Hence, gilt vacci-nation with 2 or 4 doses significantly decreased the pathogen infectious pressure, variability, and provided highantibody levels to gilts and their offspring.
Tipo de documento
Artículo
Versión del documento
Versión aceptada
Lengua
Inglés
Materias (CDU)
619 - Veterinaria
Páginas
32
Publicado por
Elsevier
Publicado en
Veterinary Microbiology
Citación
Garza-Moreno, Laura, Maria Pieters, Sergio López-Soria, Marta Carmona, Roman Krejci, Joaquim Segalés, and Marina Sibila. 2019. "Comparison Of Vaccination Protocols Against Mycoplasma Hyopneumoniae During The Gilt Acclimation Period". Veterinary Microbiology 229: 7-13. Elsevier BV. doi:10.1016/j.vetmic.2018.12.005.
Program
Sanitat Animal
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