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LysJEP8: A promising novel endolysin for combating multidrug-resistant Gram-negative bacteria
dc.contributor.author | Carratalá, Jose Vicente | |
dc.contributor.author | Ferrer‐Miralles, Neus | |
dc.contributor.author | Garcia-Fruitos, Elena | |
dc.contributor.author | Arís, Anna | |
dc.contributor.other | Producció Animal | ca |
dc.date.accessioned | 2024-09-04T13:23:29Z | |
dc.date.available | 2024-09-04T13:23:29Z | |
dc.date.issued | 2024-06-12 | |
dc.identifier.citation | Jose Vicente Carratalá, Neus Ferrer‐Miralles, Elena Garcia‐Fruitós, and Anna Arís. 2024. “LYsJEP8: A Promising Novel Endolysin for Combating Multidrug‐Resistant GRam‐Negative Bacteria.” Microbial Biotechnology 17 (6). doi:10.1111/1751-7915.14483. | ca |
dc.identifier.issn | 1751-7915 | ca |
dc.identifier.uri | http://hdl.handle.net/20.500.12327/3167 | |
dc.description.abstract | Antimicrobial resistance (AMR) is an escalating global health crisis, driven by the overuse and misuse of antibiotics. Multidrug-resistant Gram-negative bacteria, such as Pseudomonas aeruginosa, Acinetobacter baumannii, and Klebsiella pneumoniae, are particularly concerning due to their high morbidity and mortality rates. In this context, endolysins, derived from bacteriophages, offer a promising alternative to traditional antibiotics. This study introduces LysJEP8, a novel endolysin derived from Escherichia phage JEP8, which exhibits remarkable antimicrobial activity against key Gram-negative members of the ESKAPE group. Comparative assessments highlight LysJEP8's superior performance in reducing bacterial survival rates compared to previously described endolysins, with the most significant impact observed against P. aeruginosa, and notable effects on A. baumannii and K. pneumoniae. The study found that LysJEP8, as predicted by in silico analysis, worked best at lower pH values but lost its effectiveness at salt concentrations close to physiological levels. Importantly, LysJEP8 exhibited remarkable efficacy in the disruption of P. aeruginosa biofilms. This research underscores the potential of LysJEP8 as a valuable candidate for the development of innovative antibacterial agents, particularly against Gram-negative pathogens, and highlights opportunities for further engineering and optimization to address AMR effectively. | ca |
dc.description.sponsorship | The authors are indebted to the CERCA Program (Generalitat de Catalunya) and European Social Fund for supporting our research. The authors acknowledge financial support from the Agencia Española de Investigación for the granted projects (PID2019-107298RB-C21/AEI/10.13039/501100011033 to EG-F and AA, and PID2019-107298RB-C22/AEI/10.13039/501100011033 to NF-M) and to AGAUR for project 2021 SGR 01552. JVC is supported with a Margarita Salas grant for the training of young doctoral graduates (grant no. 722713). | ca |
dc.format.extent | 11 | ca |
dc.language.iso | eng | ca |
dc.publisher | Wiley | ca |
dc.relation.ispartof | Microbial Biotechnology | ca |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | ca |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.title | LysJEP8: A promising novel endolysin for combating multidrug-resistant Gram-negative bacteria | ca |
dc.type | info:eu-repo/semantics/article | ca |
dc.description.version | info:eu-repo/semantics/publishedVersion | ca |
dc.rights.accessLevel | info:eu-repo/semantics/openAccess | |
dc.embargo.terms | cap | ca |
dc.relation.projectID | MICIU/Programa Estatal de generación del conocimiento y fortalecimiento científico y tecnológico del sistema I+D+I y Programa Estatal de I+D+I orientada a los retos de la sociedad/PID2019-107298RB-C21/ES/PRODUCCION Y VALIDACION DE FARMACOS BASADOS EN PEPTIDOS DE DEFENSA DEL HUESPED PARA EL TRATAMIENTO DEL SINDROME RESPIRATORIO BOVINO/ | ca |
dc.relation.projectID | MICIU/Programa Estatal de generación del conocimiento y fortalecimiento científico y tecnológico del sistema I+D+I y Programa Estatal de I+D+I orientada a los retos de la sociedad/PID2019-107298RB-C22/ES/ / | ca |
dc.subject.udc | 579 | ca |
dc.identifier.doi | https://doi.org/10.1111/1751-7915.14483 | ca |
dc.contributor.group | Producció de Remugants | ca |
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