Empirical Bayes factor analyses of quantitative trait loci for gestation length in Iberian x Meishan F2 sows
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Author
Casellas, J.
Muñoz, G.
Ramírez, O.
Barragán, C.
Tomás, A.
Martínez-Giner, M.
Ovilo, C.
Sánchez, A.
Rodríguez, C.
Publication date
2008-02-01ISSN
1751-7311
Abstract
The aim of this study was to investigate chromosomal regions affecting gestation length in sows. An experimental F2 cross
between Iberian and Meishan pig breeds was used for this purpose and we genotyped 119 markers covering the 18 porcine
autosomal chromosomes. Within this context, we have developed a new empirical Bayes factor (BF) approach to compare
between nested models, with and without the quantitative trait loci (QTL) effect, and after including the location of the QTL
as an unknown parameter in the model. This empirical BF can be easily calculated from the output of a Markov chain
Monte Carlo sampling by averaging conditional densities at the null QTL effects. Linkage analyses were performed in each
chromosome using an animal model to account for infinitesimal genetic effects. Initially, three QTL were detected at
chromosomes 6, 8 and 11 although, after correcting for multiple testing, only the additive QTL located in cM 110 of
chromosome 8 remained. For this QTL, the allelic effect of substitution of the Iberian allele increased gestation length in
0.521 days, with a highest posterior density region at 95% ranged between 0.121 and 0.972 days. Although future studies
are necessary to confirm if detected QTL is relevant and segregating in commercial pig populations, a hot-spot on the genetic
regulation of gestation length in pigs seems to be located in chromosome 8.
Document Type
Article
Document version
Published version
Language
English
Subject (CDU)
575 - General genetics. General cytogenetics
Pages
7
Publisher
Cambridge University Press
Is part of
Animal
Citation
Casellas, J., L. Varona, G. Muñoz, O. Ramírez, C. Barragán, A. Tomás, M. Martínez-Giner, et al. 2008. “Empirical Bayes Factor Analyses of Quantitative Trait Loci for Gestation Length in Iberian × Meishan F2 Sows.” Animal 2 (2): 177–183. doi: 10.1017/s1751731107001085
Grant agreement number
MICYT/ /AGL2000-1229-C03/ES/Detección de QTLS y genes candidatos que afectan a caracteres reproductivos de interés económico en el porcino/
MEC/ /AGL2004-08368-C03/ES/Mapeo e identificación de genes que afectan a caracteres reproductivos y de supervivencia en porcino en un cruce F2 (Meishan X Ibérico), mediante técnicas de expresión diferencial y genes candidatos/GAN
Program
Genètica i Millora Animal
This item appears in the following Collection(s)
- ARTICLES CIENTÍFICS [2811]
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc-nd/4.0/