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Immunization with V987H-stabilized Spike glycoprotein protects K18-hACE2 mice and golden Syrian hamsters upon SARS-CoV-2 infection
(Nature Research, 2024-03-21)
Safe and effective severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) vaccines are crucial to fight against the coronavirus disease 2019
pandemic. Most vaccines are based on a mutated version ...
Nanoparticle-Based Secretory Granules Induce a Specific and Long-Lasting Immune Response through Prolonged Antigen Release
(MDPI, 2024-02-27)
Developing prolonged antigen delivery systems that mimic long-term exposure to pathogens
appears as a promising but still poorly explored approach to reach durable immunities. In this study,
we have ...
A Protein Misfolding Shaking Amplificationbased method for the spontaneous generation of hundreds of bona fide prions
(Nature Research, 2024-03-08)
Prion diseases are a group of rapidly progressing neurodegenerative disorders
caused by the misfolding of the endogenous prion protein (PrPC) into a
pathogenic form (PrPSc). This process, despite being ...
Immunisation efficacy of a stabilised SARS-CoV-2 spike glycoprotein in two geriatric animal models
(Nature Research, 2024-02-27)
AgeisassociatedwithreducedefficacyofvaccinesandlinkedtohigherriskofsevereCOVID-19.Herewe
determined the impact of ageing on the efficacy of a SARS-CoV-2 vaccine based on a stabilised Spike
glycoprotein ...
Exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the endangered Iberian lynx (Lynx pardinus)
(Elsevier, 2024-01-17)
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emerging zoonotic virus of public and
animal health concern, of which felids have been suggested as potential reservoirs. Although ...
Atypical disseminated histiocytic sarcoma in a 7-month-old dog: a case report
(Wiley, 2024-01-19)
A 7-month-old intact female bearded collie dog was admitted after a two-week history of
progressive cough, inappetence, and lethargy, with no response to previous treatment with
doxycycline and steroids. ...
Inefficient Transmission of African Swine Fever Virus toSentinel Pigs from an Environment Contaminated byASFV-Infected Pigs under Experimental Conditions
(Wiley, 2024-01-18)
Knowledge about African swine fever virus (ASFV) transmission and its survival in the environment is mandatory to developrational control strategies and combat this serious disease in pigs. In this ...
Elucidating the Onset of Cross-Protective Immunity after Intranasal Vaccination with the Attenuated African Swine Fever Vaccine Candidate BA71ΔCD2
(MDPI, 2024-05-09)
African swine fever (ASF) is a deadly disease of swine currently causing a worldwide
pandemic, leading to severe economic consequences for the porcine industry. The control of disease
spread is hampered ...
Field evaluation of an automated mosquito surveillance system which classifies Aedes and Culex mosquitoes by genus and sex
(BMC, 2024-03-01)
Background Mosquito‑borne diseases are a major concern for public and veterinary health authorities, highlighting
the importance of efective vector surveillance and control programs. Traditional ...
A monoclonal antibody targeting a large surface of the receptor binding motif shows pan-neutralizing SARS-CoV-2 activity
(Nature Research, 2024-02-05)
Here we report the characterization of 17T2, a SARS-CoV-2 pan-neutralizing
human monoclonal antibody isolated from a COVID-19 convalescent individual infected during the first pandemic wave. 17T2 is a ...