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A pilot RNA-seq study in 40 pietrain ejaculates to characterize the porcine sperm microbiome
(Elsevier, 2020-08-15)
The microbiome plays a key role in homeostasis and health and it has been also linked to fertility and semen quality in several animal species including swine. Despite the more than likely importance ...
Safety and Efficacy upon Infection in Sheep with Rift Valley Fever Virus ZH548-rA2, a Triple Mutant Rescued Virus
(MDPI, 2024-01-05)
The introduction of three single nucleotide mutations into the genome of the virulent RVFV
ZH548 strain allows for the rescue of a fully attenuated virus in mice (ZH548-rA2). These mutations
are located ...
Bona fide atypical scrapie faithfully reproduced for the first time in a rodent model
(BMC, 2022-12-13)
Atypical Scrapie, which is not linked to epidemics, is assumed to be an idiopathic spontaneous prion disease in small ruminants. Therefore, its occurrence is unlikely to be controlled through selective ...
Understanding the key features of the spontaneous formation of bona fde prions through a novel methodology that enables their swift and consistent generation
(BMC, 2023-09-07)
Among transmissible spongiform encephalopathies or prion diseases afecting humans, sporadic forms such as spo‑
radic Creutzfeldt–Jakob disease are the vast majority. Unlike genetic or acquired forms ...
Schlafen 12 restricts HIV-1 latency reversal by a codon-usage dependent post-transcriptional block in CD4+ T cells
(Nature Research, 2023-05-10)
Latency is a major barrier towards virus elimination in HIV-1-infected individuals. Yet, the mechanisms that contribute to the maintenance of HIV-1 latency are incompletely understood. Here we describe ...
Modelling the spatial risk of malaria through probability distribution of Anopheles maculipennis s.l. and imported cases
(Taylor and Francis, 2024-05-02)
Malaria remains one of the most important infectious diseases globally due to its high incidence and mortality rates. The
influx of infected cases from endemic to non-endemic malaria regions like Europe ...
A Protein Misfolding Shaking Amplificationbased method for the spontaneous generation of hundreds of bona fide prions
(Nature Research, 2024-03-08)
Prion diseases are a group of rapidly progressing neurodegenerative disorders
caused by the misfolding of the endogenous prion protein (PrPC) into a
pathogenic form (PrPSc). This process, despite being ...
Experimental infection of goats with Mycobacterium microti induces subclinical pulmonary tuberculosis and mild responses to tuberculin skin tests
(Elsevier, 2024-01-22)
Mycobacterium microti is a member of the Mycobacterium tuberculosis complex that seldom causes disease in
livestock and humans. This study evaluated the effects on immunodiagnosis and the pathological ...
Differential kinetics of splenic CD169+ macrophage death is one underlying cause of virus infection fate regulation
(Springer Nature, 2023-12-18)
Acute infection and chronic infection are the two most common fates of pathogenic virus infections. While several factors that
contribute to these fates are described, the critical control points and ...
Seroepidemiology of tuberculosis in sheep in southern Spain
(Elsevier, 2023-04-13)
Tuberculosis (TB) is a multi-host infectious disease caused by members of the Mycobacterium tuberculosis complex (MTC). In Mediterranean ecosystems, where multiple animal hosts of TB are present, ...