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Recombinant PrPSc shares structural features with brain-derived PrPSc: Insights from limited proteolysis
(Public Library of Science, 2018-01-31)
Very solid evidence suggests that the core of full length PrPSc is a 4-rung β-solenoid, and that individual PrPSc subunits stack to form amyloid fibers. We recently used limited proteolysis to map the ...
Experimental infection of dromedaries with Middle East respiratory syndrome-Coronavirus is accompanied by massive ciliary loss and depletion of the cell surface receptor dipeptidyl peptidase 4
(Nature Research, 2018-06-27)
Middle East respiratory syndrome (MERS) represents an important respiratory disease accompanied by lethal outcome in one-third of human patients. Recent data indicate that dromedaries represent an ...
Comparative proteomic analysis reveals different responses in porcine lymph nodes to virulent and attenuated homologous African swine fever virus strains
(BioMed Central, 2018-09-12)
African swine fever (ASF) is a pathology of pigs against which there is no treatment or vaccine. Understanding the
equilibrium between innate and adaptive protective responses and immune pathology might ...
Toxoplasma gondii infection in wild mustelids and cats across an urban-rural gradient
(Public Library of Science, 2018-06-20)
The increase in human population and domestic pets, such as cats, are generating important consequences in terms of habitat loss and pathogen pollution of coastal ecosystems with potential to generate ...
The analysis of genome composition and codon bias reveals distinctive patterns between avian and mammalian circoviruses which suggest a potential recombinant origin for Porcine circovirus 3
(Public Library of Science, 2018-06-29)
Members of the genus Circovirus are host-specific viruses, which are totally dependent on cell machinery for their replication. Consequently, certain mimicry of the host genome features is expected to ...
Low CD4/CD8 ratio in classical swine fever postnatalpersistent infection generated at 3 weeks after birth
(Wiley, 2018-11-20)
Classical swine fever virus (CSFV) is one of the most important pathogens affectingswine. After infection with a moderate virulence strain at 8 hours after birth, CSFV isable to induce viral persistence. ...
Revisiting the genetic diversity of classical swine fever virus: A proposal for new genotyping and subgenotyping schemes of classification
(Wiley, 2018-05-25)
Classical swine fever (CSF) is a highly contagious febrile viral disease caused by CSF virus (CSFV), and it is considered one of the most important infectious diseases that affect domestic pigs and wild ...
Genetic profiling of Mycobacterium bovis strains from slaughtered cattle in Eritrea
(Public Library of Science, 2018-04-17)
Mycobacterium bovis (M.bovis) is the main causative agent for bovine tuberculosis (BTB) and can also be the cause of zoonotic tuberculosis in humans. In view of its zoonotic nature, slaughterhouse ...
Development and validation of direct PCR and quantitative PCR assays for the rapid, sensitive, and economical detection of porcine circovirus 3
(SAGE Publications, 2018-04-09)
Since the identification of species Porcine circovirus 2, the relevance of genus Circovirus has increased given its impact on the swine industry. A new species (Porcine circovirus 3, PCV-3) has been ...
Detection of West Nile virus lineage 2 in North‐Eastern Spain (Catalonia)
(Wiley, 2018-12-01)
In September 2017, West Nile virus (WNV) lineage 2 was detected in Catalonia (Northern Spain) in northern goshawks by passive surveillance. The phylogenetic analyses showed that it was related to the ...