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The FlagT4G Vaccine Confers a Strong and Regulated Immunity and Early Virological Protection against Classical Swine Fever
(MDPI, 2022-09-02)
Control of classical swine fever virus (CSFV) in endemic countries relies on vaccination, mostly using vaccines that do not allow for differentiation of vaccinated from infected animals (DIVA). FlagT4G ...
Clinical course impacts early kinetics,magnitude, and amplitude of SARS-CoV-2 neutralizing antibodies beyond 1 year after infection
(Cell Press, 2022-01-24)
To understand the determinants of long-term immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the concurrent impact of vaccination and emerging variants, we follow a ...
Epidemiological surveillance of Schmallenberg virus in small ruminants in southern Spain
(Wiley, 2020-10-09)
Schmallenberg virus (SBV) is an emerging Culicoides‐borne Orthobunyavirus that affects ruminant species. Between 2011 and 2013, it was responsible for a large‐scale epidemic in Europe. In the present ...
Zoonotic diseases: Can the transmission of pathogens between animals and humans be controlled?
(Universitat de Valencia, 2023-02-23)
After being associated with more than six million deaths so far, the Covid-19 pandemic is one of the worst diseases of animal origin known to date. Other zoonotic diseases such as severe acute respiratory ...
Cross-protection against African swine fever virus upon intranasal vaccination is associated with an adaptive-innate immune crosstalk
(Public Library of Science, 2022-11-09)
African swine fever virus (ASFV) is causing a worldwide pandemic affecting the porcine industry and leading to important global economic consequences. The virus causes a highly lethal hemorrhagic disease ...
XCR1+ DCs are critical for T cell-mediated immunotherapy of chronic viral infections
(Cell Press, 2023-02-14)
The contribution of cross-presenting XCR1+ dendritic cells (DCs) and SIRPα+ DCs in maintaining T cell function during exhaustion and immunotherapeutic interventions of chronic infections remains poorly ...
Leveraging host-genetics and gut microbiota to determine immunocompetence in pigs
(BMC, 2021-10-24)
Background: The gut microbiota infuences host performance playing a relevant role in homeostasis and function of
the immune system. The aim of the present work was to identify microbial signatures ...
Pathological findings in genital organs of bulls naturally infected with Besnoitia besnoiti
(Springer, 2020-05-26)
Bulls chronically affected by bovine besnoitiosis can suffer from sterility. There is limited information about the distribution of Besnoitia cysts and their associated lesions within the male genital ...
Viromics on honey-baited FTA cards as a new tool for the detection of circulating viruses in mosquitoes
(MDPI, 2020-02-29)
Worldwide, emerging and re-emerging infectious diseases (EIDs) are a major burden on public and animal health. Arthropod vectors, with mosquitoes being the main contributors of global disease, transmit ...
Preclinical and randomized phase I studies of plitidepsin in adults hospitalized with COVID-19
(Life Science Alliance, 2022-01-10)
Plitidepsin, a marine-derived cyclic-peptide, inhibits SARS-CoV-2 replication at nanomolar concentrations by targeting the host protein eukaryotic translation elongation factor 1A. Here, we show that ...