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The emergence of classical BSE from atypical/Nor98 scrapie
(National Academy of Sciences, 2019-12-16)
Atypical/Nor98 scrapie (AS) is a prion disease of small ruminants. Currently there are no efficient measures to control this form of prion disease, and, importantly, the zoonotic potential and the risk ...
Transmission of tuberculosis caused by Mycobacterium caprae between dairy sheep and goats
(Elsevier, 2017-11-24)
Increasing number of caprine tuberculosis (TB) reports grant the consideration of this zoonosis as an emergingdisease that can play a role in the epidemiology of bovine TB in endemic areas. An outbreak ...
Development of a new largely scalable in vitro prion propagation method for the production of infectious recombinant prions for high resolution structural studies
(Public Library of Science, 2019-10-23)
The resolution of the three-dimensional structure of infectious prions at the atomic level is pivotal to understand the pathobiology of Transmissible Spongiform Encephalopathies (TSE), but has been long ...
Mycobacterium microti Infection in free-ranging wild boar, Spain, 2017-2019
(Centers for Disease Control and Prevention, 2019-11-25)
Mycobacterium microti is a member of the Mycobacterium tuberculosis complex that causes pathology in many mammals. M. microti infections have been found in some countries in Europe. We report an outbreak ...
DNA vaccine based on conserved HA-peptides induces strong immune response and rapidly clears influenza virus infection from vaccinated pigs
(Public Library of Science, 2019-09-25)
Swine influenza virus (SIVs) infections cause a significant economic impact to the pork industry.
Moreover, pigs may act as mixing vessel favoring genome reassortment of diverse influenza
viruses. ...
Efficacy of parenteral vaccination against tuberculosis with heat-inactivated Mycobacterium bovis in experimentally challenged goats
(Public Library of Science, 2018-05-09)
Tuberculosis (TB) in animals is a re-emerging disease with a wide range of hosts that
causes large economic losses in livestock. Goats are particularly susceptible to TB and, in
endemic areas, vaccination ...
A Rift Valley fever virus Gn ectodomain-based DNA vaccine induces a partial protection not improved by APC targeting
(Nature Research, 2018-04-20)
Rift Valley fever virus, a phlebovirus endemic in Africa, causes serious diseases in ruminants and humans. Due to the high probability of new outbreaks and spread to other continents where competent ...
Systems analysis reveals complex biological processes during virus infection fate decisions
(Cold Spring Harbor Laboratory Press, 2019-05-28)
The processes and mechanisms of virus infection fate decisions that are the result of a dynamic virus-immune system interaction with either an efficient effector response and virus elimination or an ...
Protective effect of a polyvalent influenza DNA vaccine in pigs
(Elsevier, 2017-11-23)
Background: Influenza A virus in swine herds represents a major problem for the swine industry and poses a
constant threat for the emergence of novel pandemic viruses and the development of more effective ...
Recombinant PrPSc shares structural features with brain-derived PrPSc: Insights from limited proteolysis
(Public Library of Science, 2018-01-31)
Very solid evidence suggests that the core of full length PrPSc is a 4-rung β-solenoid, and that individual PrPSc subunits stack to form amyloid fibers. We recently used limited proteolysis to map the ...