• Immunization with V987H-stabilized Spike glycoprotein protects K18-hACE2 mice and golden Syrian hamsters upon SARS-CoV-2 infection 

      Ávila-Nieto, Carlos; Vergara-Alert, Júlia; Amengual-Rigo, Pep; Ainsua-Enrich, Erola; Brustolin, Marco; Rodríguez de la Concepción, María Luisa; Pedreño-Lopez, Núria; Rodon, Jordi; Urrea, Victor; Pradenas, Edwards; Marfil, Silvia; Ballana, Ester; Riveira-Muñoz, Eva; Pérez, Mònica; Roca, Núria; Tarrés-Freixas, Ferran; Cantero, Guillermo; Pons-Grífols, Anna; Rovirosa, Carla; Aguilar-Gurrieri, Carmen; Ortiz, Raquel; Barajas, Ana; Trinité, Benjamin; Lepore, Rosalba; Muñoz-Basagoiti, Jordana; Perez-Zsolt, Daniel; Izquierdo-Useros, Nuria; Valencia, Alfonso; Blanco, Julià; Guallar, Victor; Clotet, Bonaventura; Segalés, Joaquim; Carrillo, Jorge (Nature Communications, 2024-03-21) Sanitat Animal
      Safe and effective severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) vaccines are crucial to fight against the coronavirus disease 2019 pandemic. Most vaccines are based on a mutated version ...
    • Novel Spike-stabilized trimers with improved production protect K18-hACE2 mice and golden Syrian hamsters from the highly pathogenic SARS-CoV-2 Beta variant 

      Ávila-Nieto, Carlos; Vergara-Alert, Júlia; Amengual-Rigo, Pep; Ainsua-Enrich, Erola; Brustolin, Marco; Rodríguez de la Concepción, María Luisa; Pedreño-Lopez, Núria; Rodon, Jordi; Urrea, Victor; Pradenas, Edwards; Marfil, Silvia; Ballana, Ester; Riveira-Muñoz, Eva; Pérez, Mònica; Roca, Núria; Tarrés-Freixas, Ferran; Carabelli, Julieta; Cantero, Guillermo; Pons-Grífols, Anna; Rovirosa, Carla; Aguilar-Gurrieri, Carmen; Ortiz, Raquel; Barajas, Ana; Trinité, Benjamin; Lepore, Rosalba; Muñoz-Basagoiti, Jordana; Perez-Zsolt, Daniel; Izquierdo-Useros, Nuria; Valencia, Alfonso; Blanco, Julià; Clotet, Bonaventura; Guallar, Victor; Segalés, Joaquim; Carrillo, Jorge (Frontiers in Immunology, 2023-12-04) Sanitat Animal
      Most COVID-19 vaccines are based on the SARS-CoV-2 Spike glycoprotein (S) or their subunits. However, S shows some structural instability that limits its immunogenicity and production, hampering the ...
    • SARS-CoV-2 infection elicits a rapid neutralizing antibody response that correlates with disease severity 

      Trinité, Benjamin; Tarrés-Freixas, Ferran; Rodon, Jordi; Pradenas, Edwards; Urrea, Víctor; Marfil, Silvia; Rodríguez de la Concepción, María Luisa; Ávila-Nieto, Carlos; Aguilar-Gurrieri, Carmen; Barajas, Ana; Ortiz, Raquel; Paredes, Roger; Mateu, Lourdes; Valencia, Alfonso; Guallar, Víctor; Ruiz, Lidia; Grau, Eulàlia; Massanella, Marta; Puig, Jordi; Chamorro, Anna; Izquierdo-Useros, Nuria; Segalés, Joaquim; Clotet, Bonaventura; Carrillo, Jorge; Vergara-Alert, Júlia; Blanco, Julià (Scientific Reports, 2021-01-28) Sanitat Animal
      The protective effect of neutralizing antibodies in SARS-CoV-2 infected individuals is not yet well defined. To address this issue, we have analyzed the kinetics of neutralizing antibody responses and ...