Browsing ARTICLES CIENTÍFICS by Author "Izquierdo-Useros, Nuria"

Now showing items 1-20 of 25

    • A monoclonal antibody targeting a large surface of the receptor binding motif shows pan-neutralizing SARS-CoV-2 activity 

      de Campos-Mata, Leire; Trinité, Benjamin; Modrego, Andrea; Tejedor Vaquero, Sonia; Pradenas, Edwards; Pons-Grífols, Anna; Rodrigo Melero, Natalia; Carlero, Diego; Marfil, Silvia; Santiago, César; Raïch-Regué, Dàlia; Bueno-Carrasco, María Teresa; Tarrés Freixas, Ferran; Abancó, Ferran; Urrea, Victor; Izquierdo-Useros, Nuria; Riveira-Muñoz, Eva; Ballana, Ester; Pérez, Mónica; Vergara-Alert, Júlia; Segalés, Joaquim; Carolis, Carlo; Arranz, Rocío; Blanco, Julià; Magri, Giuliana (Nature Communications, 2024-02-05) Sanitat Animal
      Here we report the characterization of 17T2, a SARS-CoV-2 pan-neutralizing human monoclonal antibody isolated from a COVID-19 convalescent individual infected during the first pandemic wave. 17T2 is a ...

    • Agreement and differential use of laboratory methods for the detection and quantification of SARS-CoV-2 in experimentally infected animals 

      Usai, Carla; Pailler García, Lola; Lorca-Oró, Cristina; Fernández-Bastit, Leira; Roca, Núria; Brustolin, Marco; Rodon Aldrufeu, Jordi; Pérez, Mónica; Cantero Portillo, Guillermo; Carrillo, Jorge; Izquierdo-Useros, Nuria; Blanco, Julià; Clotet, Bonaventura; Napp, Sebastian; Segalés, Joaquim; Vergara-Alert, Júlia (Frontiers in Microbiology, 2022-11-15) Sanitat Animal
      Rodents are widely used for the development of COVID-19-like animal models, the virological outcome being determined through several laboratory methods reported in the literature. Our objective was to ...

    • An anti-SARS-CoV-2 metabolite is reduced in diabetes 

      Vergara-Alert, Júlia; Izquierdo-Useros, Nuria (Nature Metabolism, 2022-05-09) Sanitat Animal
      A glucose-like metabolite, which is reduced in the serum of diabetic patients, inhibits the entry of SARS-CoV-2 into key cellular targets. The work led by Cheng and colleagues provides a molecular ...

    • Chronological brain lesions after SARS-CoV-2 infection in hACE2-transgenic mice 

      Vidal, Enric; López-Figueroa, Carlos; Rodon, Jordi; Pérez, Mónica; Brustolin, Marco; Cantero, Guillermo; Guallar, Víctor; Izquierdo-Useros, Nuria; Carrillo, Jorge; Blanco, Julià; Clotet, Bonaventura; Vergara-Alert, Júlia; Segalés, Joaquim (Veterinary Pathology, 2021-12-27) Sanitat Animal
      Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes respiratory disease, but it can also affect other organs including the central nervous system. Several animal models have been developed ...

    • Clinical course impacts early kinetics,magnitude, and amplitude of SARS-CoV-2 neutralizing antibodies beyond 1 year after infection 

      Pradenas, Edwards; Trinité, Benjamin; Urrea, Víctor; Marfil, Silvia; Tarrés-Freixas, Ferran; Ortiz, Raquel; Rovirosa, Carla; Rodon, Jordi; Vergara-Alert, Júlia; Segalés, Joaquim; Guallar, Victor; Valencia, Alfonso; Izquierdo-Useros, Nuria; Noguera-Julian, Marc; Carrillo, Jorge; Paredes, Roger; Mateu, Lourdes; Chamorro, Anna; Toledo, Ruth; Massanella, Marta; Clotet, Bonaventura; Blanco, Julià (Cell Reports Medicine, 2022-01-24) Sanitat Animal
      To understand the determinants of long-term immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the concurrent impact of vaccination and emerging variants, we follow a ...

    • Detection of SARS-CoV-2 in a cat owned by a COVID-19−affected patient in Spain 

      Segalés, Joaquim; Puig, Mariona; Rodon, Jordi; Avila-Nieto, Carlos; Carrillo, Jorge; Cantero, Guillermo; Terrón, Maria Teresa; Cruz, Sílvia; Parera, Mariona; Noguera-Julián, Marc; Izquierdo-Useros, Nuria; Guallar, Víctor; Vidal, Enric; Valencia, Alfonso; Blanco, Ignacio; Blanco, Julià; Clotet, Bonaventura; Vergara-Alert, Júlia (Proceedings of the National Academy of Sciences (PNAS), 2020-09-18) Sanitat Animal
      Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent of COVID-19, is considered a zoonotic pathogen mainly transmitted human to human. Few reports indicate that pets may ...

    • First Detection of SARS-CoV-2 Delta (B.1.617.2) Variant of Concern in a Dog with Clinical Signs in Spain 

      Fernández-Bastit, Leira; Rodon, Jordi; Pradenas, Edwards; Marfil, Silvia; Trinité, Benjamin; Parera, Mariona; Roca, Núria; Pou, Anna; Cantero, Guillermo; Lorca-Oró, Cristina; Carrillo, Jorge; Izquierdo-Useros, Nuria; Clotet, Bonaventura; Noguera-Julián, Marc; Blanco, Julià; Vergara-Alert, Júlia; Segalés, Joaquim (Viruses, 2021-12-16) Sanitat Animal
      Several cases of naturally infected dogs with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been reported despite the apparently low susceptibility of this species. Here, we document ...

    • Heterogeneous Infectivity and Pathogenesis of SARS-CoV-2 Variants Beta, Delta and Omicron in Transgenic K18-hACE2 and Wildtype Mice 

      Tarrés-Freixas, Ferran; Trinité, Benjamin; Pons-Grífols, Anna; Romero-Durana, Miguel; Riveira-Muñoz, Eva; Ávila-Nieto, Carlos; Pérez, Mónica; Garcia-Vidal, Edurne; Perez-Zsolt, Daniel; Muñoz-Basagoiti, Jordana; Raïch-Regué, Dàlia; Izquierdo-Useros, Nuria; Andrés, Cristina; Antón, Andrés; Pumarola, Tomàs; Blanco, Ignacio; Noguera-Julián, Marc; Guallar, Victor; Lepore, Rosalba; Valencia, Alfonso; Urrea, Victor; Vergara-Alert, Júlia; Clotet, Bonaventura; Ballana, Ester; Carrillo, Jorge; Segalés, Joaquim; Blanco, Julià (Frontiers in Microbiology, 2022-05-04) Sanitat Animal
      The emerging SARS-CoV-2 variants of concern (VOCs) may display enhanced transmissibility, more severity and/or immune evasion; however, the pathogenesis of these new VOCs in experimental SARS-CoV-2 ...

    • Identification of Plitidepsin as Potent Inhibitor of SARS-CoV-2-Induced Cytopathic Effect After a Drug Repurposing Screen 

      Rodon, Jordi; Muñoz-Basagoit, Jordana; Perez-Zsolt, Daniel; Noguera-Julian, Marc; Paredes, Roger; Mateu, Lourdes; Quiñones, Carles; Perez, Carles; Erkizia, Itziar; Blanco, Ignacio; Valencia, Alfonso; Guallar, Víctor; Carrillo, Jorge; Blanco, Julià; Segalés, Joaquim; Clotet, Bonaventura; Vergara-Alert, Júlia; Izquierdo-Useros, Nuria (Frontiers in Pharmacology, 2021-03-25) Sanitat Animal
      There is an urgent need to identify therapeutics for the treatment of Coronavirus disease 2019 (COVID-19). Although different antivirals are given for the clinical management of SARS-CoV-2 infection, ...

    • Immunisation efficacy of a stabilised SARS-CoV-2 spike glycoprotein in two geriatric animal models 

      Usai, Carla; Ainsua-Enrich, Erola; Urrea Gales, Victor; Pradenas, Edwards; Lorca-Oró, Cristina; Tarrés Freixas, Ferran; Roca, Núria; Pérez Maíllo, Mónica; Ávila-Nieto, Carlos; Rodríguez de la Concepción, María Luisa; Pedreño-Lopez, Núria; Carabelli, Julieta; Trinité, Benjamin; Ballana, Ester; Riveira-Muñoz, Eva; Izquierdo-Useros, Nuria; Clotet, Bonaventura; Blanco, Julià; Guallar, Victor; Cantero Portillo, Guillermo; Vergara-Alert, Júlia; Carrillo, Jorge; Segalés, Joaquim (npj Vaccines, 2024-02-27) Sanitat Animal
      AgeisassociatedwithreducedefficacyofvaccinesandlinkedtohigherriskofsevereCOVID-19.Herewe determined the impact of ageing on the efficacy of a SARS-CoV-2 vaccine based on a stabilised Spike glycoprotein ...

    • Immunization with V987H-stabilized Spike glycoprotein protects K18-hACE2 mice and golden Syrian hamsters upon SARS-CoV-2 infection 

      Ávila-Nieto, Carlos; Vergara-Alert, Júlia; Amengual-Rigo, Pep; Ainsua-Enrich, Erola; Brustolin, Marco; Rodríguez de la Concepción, María Luisa; Pedreño-Lopez, Núria; Rodon, Jordi; Urrea, Victor; Pradenas, Edwards; Marfil, Silvia; Ballana, Ester; Riveira-Muñoz, Eva; Pérez, Mònica; Roca, Núria; Tarrés-Freixas, Ferran; Cantero, Guillermo; Pons-Grífols, Anna; Rovirosa, Carla; Aguilar-Gurrieri, Carmen; Ortiz, Raquel; Barajas, Ana; Trinité, Benjamin; Lepore, Rosalba; Muñoz-Basagoiti, Jordana; Perez-Zsolt, Daniel; Izquierdo-Useros, Nuria; Valencia, Alfonso; Blanco, Julià; Guallar, Victor; Clotet, Bonaventura; Segalés, Joaquim; Carrillo, Jorge (Nature Communications, 2024-03-21) Sanitat Animal
      Safe and effective severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) vaccines are crucial to fight against the coronavirus disease 2019 pandemic. Most vaccines are based on a mutated version ...

    • Kinetics of immune responses elicited after three mRNA COVID-19 vaccine doses in predominantly antibody-deficient individuals 

      Ainsua-Enrich, Erola; Pedreño-Lopez, Núria; Bracke, Carmen; Ávila-Nieto, Carlos; Rodríguez de la Concepción, María Luisa; Pradenas, Edwards; Trinité, Benjamin; Marfil, Silvia; Miranda, Cristina; González, Sandra; Toledo, Ruth; Font, Marta; Benet, Susana; Escribà, Tuixent; Jimenez-Moyano, Esther; Peña, Ruth; Cedeño, Samandhy; Prado, Julia G.; Mothe, Beatriz; Brander, Christian; Izquierdo-Useros, Nuria; Vergara-Alert, Júlia; Segalés, Joaquim; Massanella, Marta; Benitez, Rosa María; Romero, Alba; Molina-Morant, Daniel; Blanco, Julià; Clotet, Bonaventura; Mateu, Lourdes; Pedro-Botet, María Luisa; Carrillo, Jorge (iScience, 2022-10-28) Sanitat Animal
      Mass vaccination campaigns reduced COVID-19 incidence and severity. Here, we evaluated the immune responses developed in SARS-CoV-2-uninfected patients with predominantly antibody-deficiencies (PAD) ...

    • Monitoring Natural SARS-CoV-2 Infection in Lions (Panthera leo) at the Barcelona Zoo: Viral Dynamics and Host Responses 

      Fernández-Bellon, Hugo; Rodon, Jordi; Fernández-Bastit, Leira; Almagro, Vanessa; Padilla-Solé, Pilar; Lorca-Oró, Cristina; Valle, Rosa; Roca, Núria; Grazioli, Santina; Trogu, Tiziana; Bensaid, Albert; Carrillo, Jorge; Izquierdo-Useros, Nuria; Blanco, Julià; Parera, Mariona; Noguera-Julián, Marc; Clotet, Bonaventura; Moreno, Ana; Segalés, Joaquim; Vergara-Alert, Júlia (Viruses, 2021-08-25) Sanitat Animal
      To date, no evidence supports the fact that animals play a role in the epidemiology of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the coronavirus infectious ...

    • Mycobacterium manresensis induces trained immunity in vitro 

      de Homdedeu, Miquel; Sanchez-Moral, Lidia; Violán, Concepció; Ràfols, Neus; Ouchi, Dan; Martín, Berta; Peinado, Miguel A.; Rodríguez-Cortés, Alhelí; Arch-Sisquella, Marta; Perez-Zsolt, Daniel; Muñoz Basagoiti, Jordana; Izquierdo-Useros, Nuria; Salvador, Betlem; Matllo, Joan; López-Serrano, Sergi; Segalés, Joaquim; Vilaplana, Cristina; Torán-Monserrat, Pere; Morros, Rosa; Monfà, Ramon; Sarrias, Maria-Rosa; Cardona, Pere-Joan (iScience, 2023-05-13) Sanitat Animal
      The COVID-19 pandemic posed a global health crisis, with new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants weakening vaccine-driven protection. Trained immunity could help tackle ...

    • Novel Spike-stabilized trimers with improved production protect K18-hACE2 mice and golden Syrian hamsters from the highly pathogenic SARS-CoV-2 Beta variant 

      Ávila-Nieto, Carlos; Vergara-Alert, Júlia; Amengual-Rigo, Pep; Ainsua-Enrich, Erola; Brustolin, Marco; Rodríguez de la Concepción, María Luisa; Pedreño-Lopez, Núria; Rodon, Jordi; Urrea, Victor; Pradenas, Edwards; Marfil, Silvia; Ballana, Ester; Riveira-Muñoz, Eva; Pérez, Mònica; Roca, Núria; Tarrés-Freixas, Ferran; Carabelli, Julieta; Cantero, Guillermo; Pons-Grífols, Anna; Rovirosa, Carla; Aguilar-Gurrieri, Carmen; Ortiz, Raquel; Barajas, Ana; Trinité, Benjamin; Lepore, Rosalba; Muñoz-Basagoiti, Jordana; Perez-Zsolt, Daniel; Izquierdo-Useros, Nuria; Valencia, Alfonso; Blanco, Julià; Clotet, Bonaventura; Guallar, Victor; Segalés, Joaquim; Carrillo, Jorge (Frontiers in Immunology, 2023-12-04) Sanitat Animal
      Most COVID-19 vaccines are based on the SARS-CoV-2 Spike glycoprotein (S) or their subunits. However, S shows some structural instability that limits its immunogenicity and production, hampering the ...

    • Pigs are not susceptible to SARS‐CoV‐2 infection but are a model for viral immunogenicity studies 

      Vergara-Alert, Júlia; Rodon, Jordi; Carrillo, Jorge; Te, Nigeer; Izquierdo-Useros, Nuria; Rodríguez de la Concepción, María Luisa; Ávila-Nieto, Carlos; Guallar, Víctor; Valencia, Alfonso; Cantero, Guillermo; Blanco, Julià; Clotet, Buenaventura; Bensaid, Albert; Segalés, Joaquim (Transboundary and Emerging Diseases, 2020-10-02) Sanitat Animal
      Conventional piglets were inoculated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) through different routes, including intranasal, intratracheal, intramuscular and intravenous ones. ...

    • Preclinical and randomized phase I studies of plitidepsin in adults hospitalized with COVID-19 

      Varona, Jose F.; Landete, Pedro; Lopez-Martin, Jose A.; Estrada, Vicente; Paredes, Roger; Guisado-Vasco, Pablo; Fernandez de Orueta, Lucia; Torralba, Miguel; Fortun, Jesus; Vates, Roberto; Barberan, Jose; Clotet, Bonaventura; Ancochea, Julio; Carnevali, Daniel; Cabello, Noemi; Porras, Lourdes; Gijon, Paloma; Monereo, Alfonso; Abad, Daniel; Zuñiga, Sonia; Sola, Isabel; Rodon, Jordi; Vergara-Alert, Julia; Izquierdo-Useros, Nuria; Fudio, Salvador; Pontes, Maria Jose; de Rivas, Beatriz; Giron de Velasco, Patricia; Nieto, Antonio; Gomez, Javier; Aviles, Pablo; Lubomirov, Rubin; Belgrano, Alvaro; Sopesen, Belen; White, Kris M.; Rosales, Romel; Yildiz, Soner; Reuschl, Ann-Kathrin; Thorne, Lucy G.; Jolly, Clare; Towers, Greg J.; Zuliani-Alvarez, Lorena; Bouhaddou, Mehdi; Obernier, Kirsten; McGovern, Briana L.; Rodriguez, M. Luis; Enjuanes, Luis; Fernandez-Sousa, Jose M.; Krogan, Nevan J.; Jimeno, Jose M.; Garcia-Sastre, Adolfo (Life Science Alliance, 2022-01-10) Sanitat Animal
      Plitidepsin, a marine-derived cyclic-peptide, inhibits SARS-CoV-2 replication at nanomolar concentrations by targeting the host protein eukaryotic translation elongation factor 1A. Here, we show that ...

    • Previous SARS-CoV-2 Infection Increases B.1.1.7 Cross-Neutralization by Vaccinated Individuals 

      Trinité, Benjamin; Pradenas, Edwards; Marfil, Silvia; Rovirosa, Carla; Urrea, Víctor; Tarrés-Freixas, Ferran; Ortiz, Raquel; Rodon, Jordi; Vergara-Alert, Júlia; Segalés, Joaquim; Guallar, Victor; Lepore, Rosalba; Izquierdo-Useros, Nuria; Trujillo, Glòria; Trapé, Jaume; González-Fernández, Carolina; Flor, Antonia; Pérez-Vidal, Rafel; Toledo, Ruth; Chamorro, Anna; Paredes, Roger; Blanco, Ignacio; Grau, Eulàlia; Massanella, Marta; Carrillo, Jorge; Clotet, Bonaventura; Blanco, Julià (Viruses, 2021-06-12) Sanitat Animal
      With the spread of new variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), there is a need to assess the protection conferred by both previous infections and current vaccination. ...

    • Protection against reinfection with D614- or G614-SARS-CoV-2 isolates in golden Syrian hamster 

      Brustolin, Marco; Rodon, Jordi; Rodríguez de la Concepción, María Luisa; Ávila-Nieto, Carlos; Cantero, Guillermo; Pérez, Mónica; Te, Nigeer; Noguera-Julián, Marc; Guallar, Víctor; Valencia, Alfonso; Roca, Núria; Izquierdo-Useros, Nuria; Blanco, Julià; Clotet, Bonaventura; Bensaid, Albert; Carrillo, Jorge; Vergara-Alert, Júlia; Segalés, Joaquim (Emerging Microbes and Infections, 2021-04-29) Sanitat Animal
      Reinfections with SARS-CoV-2 have already been documented in humans, although its real incidence is currently unknown. Besides having a great impact on public health, this phenomenon raises the question ...

    • SARS-CoV-2 infection elicits a rapid neutralizing antibody response that correlates with disease severity 

      Trinité, Benjamin; Tarrés-Freixas, Ferran; Rodon, Jordi; Pradenas, Edwards; Urrea, Víctor; Marfil, Silvia; Rodríguez de la Concepción, María Luisa; Ávila-Nieto, Carlos; Aguilar-Gurrieri, Carmen; Barajas, Ana; Ortiz, Raquel; Paredes, Roger; Mateu, Lourdes; Valencia, Alfonso; Guallar, Víctor; Ruiz, Lidia; Grau, Eulàlia; Massanella, Marta; Puig, Jordi; Chamorro, Anna; Izquierdo-Useros, Nuria; Segalés, Joaquim; Clotet, Bonaventura; Carrillo, Jorge; Vergara-Alert, Júlia; Blanco, Julià (Scientific Reports, 2021-01-28) Sanitat Animal
      The protective effect of neutralizing antibodies in SARS-CoV-2 infected individuals is not yet well defined. To address this issue, we have analyzed the kinetics of neutralizing antibody responses and ...