• A monoclonal antibody targeting a large surface of the receptor binding motif shows pan-neutralizing SARS-CoV-2 activity 

      de Campos-Mata, Leire; Trinité, Benjamin; Modrego, Andrea; Tejedor Vaquero, Sonia; Pradenas, Edwards; Pons-Grífols, Anna; Rodrigo Melero, Natalia; Carlero, Diego; Marfil, Silvia; Santiago, César; Raïch-Regué, Dàlia; Bueno-Carrasco, María Teresa; Tarrés Freixas, Ferran; Abancó, Ferran; Urrea, Victor; Izquierdo-Useros, Nuria; Riveira-Muñoz, Eva; Ballana, Ester; Pérez, Mónica; Vergara-Alert, Júlia; Segalés, Joaquim; Carolis, Carlo; Arranz, Rocío; Blanco, Julià; Magri, Giuliana (Nature Communications, 2024-02-05) Sanitat Animal
      Here we report the characterization of 17T2, a SARS-CoV-2 pan-neutralizing human monoclonal antibody isolated from a COVID-19 convalescent individual infected during the first pandemic wave. 17T2 is a ...
    • Critical Presentation of a Severe Acute Respiratory Syndrome Coronavirus 2 Reinfection: A Case Report 

      Massanella, Marta; Martin-Urda, Anabel; Mateu, Lourdes; Marín, Toni; Aldas, Irene; Riveira-Muñoz, Eva; Kipelainen, Athina; Jiménez-Moyano, Esther; Rodriguez de la Concepción, Maria Luisa; Avila-Nieto, Carlos; Trinité, Benjamin; Pradenas, Edwards; Rodon, Jordi; Marfil, Silvia; Parera, Mariona; Carrillo, Jorge; Blanco, Julià; Prado, Julia G.; Ballana, Ester; Vergara-Alert, Júlia; Segalés, Joaquim; Noguera-Julian, Marc; Masabeu, Àngels; Clotet, Bonaventura; Toda, Maria de la Roca; Paredes, Roger (Open Forum Infectious Diseases, 2021-06-23) Sanitat Animal
      Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reinfections have been reported; however, most cases are milder than the primary infection. We report the first case of a ...
    • Heterogeneous Infectivity and Pathogenesis of SARS-CoV-2 Variants Beta, Delta and Omicron in Transgenic K18-hACE2 and Wildtype Mice 

      Tarrés-Freixas, Ferran; Trinité, Benjamin; Pons-Grífols, Anna; Romero-Durana, Miguel; Riveira-Muñoz, Eva; Ávila-Nieto, Carlos; Pérez, Mónica; Garcia-Vidal, Edurne; Perez-Zsolt, Daniel; Muñoz-Basagoiti, Jordana; Raïch-Regué, Dàlia; Izquierdo-Useros, Nuria; Andrés, Cristina; Antón, Andrés; Pumarola, Tomàs; Blanco, Ignacio; Noguera-Julián, Marc; Guallar, Victor; Lepore, Rosalba; Valencia, Alfonso; Urrea, Victor; Vergara-Alert, Júlia; Clotet, Bonaventura; Ballana, Ester; Carrillo, Jorge; Segalés, Joaquim; Blanco, Julià (Frontiers in Microbiology, 2022-05-04) Sanitat Animal
      The emerging SARS-CoV-2 variants of concern (VOCs) may display enhanced transmissibility, more severity and/or immune evasion; however, the pathogenesis of these new VOCs in experimental SARS-CoV-2 ...
    • Immunisation efficacy of a stabilised SARS-CoV-2 spike glycoprotein in two geriatric animal models 

      Usai, Carla; Ainsua-Enrich, Erola; Urrea Gales, Victor; Pradenas, Edwards; Lorca-Oró, Cristina; Tarrés Freixas, Ferran; Roca, Núria; Pérez Maíllo, Mónica; Ávila-Nieto, Carlos; Rodríguez de la Concepción, María Luisa; Pedreño-Lopez, Núria; Carabelli, Julieta; Trinité, Benjamin; Ballana, Ester; Riveira-Muñoz, Eva; Izquierdo-Useros, Nuria; Clotet, Bonaventura; Blanco, Julià; Guallar, Victor; Cantero Portillo, Guillermo; Vergara-Alert, Júlia; Carrillo, Jorge; Segalés, Joaquim (npj Vaccines, 2024-02-27) Sanitat Animal
      AgeisassociatedwithreducedefficacyofvaccinesandlinkedtohigherriskofsevereCOVID-19.Herewe determined the impact of ageing on the efficacy of a SARS-CoV-2 vaccine based on a stabilised Spike glycoprotein ...
    • Immunization with V987H-stabilized Spike glycoprotein protects K18-hACE2 mice and golden Syrian hamsters upon SARS-CoV-2 infection 

      Ávila-Nieto, Carlos; Vergara-Alert, Júlia; Amengual-Rigo, Pep; Ainsua-Enrich, Erola; Brustolin, Marco; Rodríguez de la Concepción, María Luisa; Pedreño-Lopez, Núria; Rodon, Jordi; Urrea, Victor; Pradenas, Edwards; Marfil, Silvia; Ballana, Ester; Riveira-Muñoz, Eva; Pérez, Mònica; Roca, Núria; Tarrés-Freixas, Ferran; Cantero, Guillermo; Pons-Grífols, Anna; Rovirosa, Carla; Aguilar-Gurrieri, Carmen; Ortiz, Raquel; Barajas, Ana; Trinité, Benjamin; Lepore, Rosalba; Muñoz-Basagoiti, Jordana; Perez-Zsolt, Daniel; Izquierdo-Useros, Nuria; Valencia, Alfonso; Blanco, Julià; Guallar, Victor; Clotet, Bonaventura; Segalés, Joaquim; Carrillo, Jorge (Nature Communications, 2024-03-21) Sanitat Animal
      Safe and effective severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) vaccines are crucial to fight against the coronavirus disease 2019 pandemic. Most vaccines are based on a mutated version ...
    • Novel Spike-stabilized trimers with improved production protect K18-hACE2 mice and golden Syrian hamsters from the highly pathogenic SARS-CoV-2 Beta variant 

      Ávila-Nieto, Carlos; Vergara-Alert, Júlia; Amengual-Rigo, Pep; Ainsua-Enrich, Erola; Brustolin, Marco; Rodríguez de la Concepción, María Luisa; Pedreño-Lopez, Núria; Rodon, Jordi; Urrea, Victor; Pradenas, Edwards; Marfil, Silvia; Ballana, Ester; Riveira-Muñoz, Eva; Pérez, Mònica; Roca, Núria; Tarrés-Freixas, Ferran; Carabelli, Julieta; Cantero, Guillermo; Pons-Grífols, Anna; Rovirosa, Carla; Aguilar-Gurrieri, Carmen; Ortiz, Raquel; Barajas, Ana; Trinité, Benjamin; Lepore, Rosalba; Muñoz-Basagoiti, Jordana; Perez-Zsolt, Daniel; Izquierdo-Useros, Nuria; Valencia, Alfonso; Blanco, Julià; Clotet, Bonaventura; Guallar, Victor; Segalés, Joaquim; Carrillo, Jorge (Frontiers in Immunology, 2023-12-04) Sanitat Animal
      Most COVID-19 vaccines are based on the SARS-CoV-2 Spike glycoprotein (S) or their subunits. However, S shows some structural instability that limits its immunogenicity and production, hampering the ...