Buscar
Mostrando ítems 11-20 de 33
High-Fat Diet-Induced Obesity Increases Brain Mitochondrial Complex I and Lipoxidation-Derived Protein Damage
(MDPI, 2024-01-26)
Obesity is a risk factor for highly prevalent age-related neurodegenerative diseases, the pathogenesis of whichinvolves mitochondrial dysfunction and protein oxidative damage. Lipoxidation, driven by ...
Understanding the key features of the spontaneous formation of bona fde prions through a novel methodology that enables their swift and consistent generation
(BMC, 2023-09-07)
Among transmissible spongiform encephalopathies or prion diseases afecting humans, sporadic forms such as spo‑
radic Creutzfeldt–Jakob disease are the vast majority. Unlike genetic or acquired forms ...
Functional Evolution of Clustered Aquaporin Genes Reveals Insights into the Oceanic Success of Teleost Eggs
(Oxford University Press, 2023-03-22)
Aquaporin-mediated oocyte hydration is considered important for the evolution of pelagic eggs and the radiative success of marine teleosts. However, the molecular regulatory mechanisms controlling this ...
Integrating spatiotemporal hydrological connectivity into conservation planning to protect temporary rivers
(Wiley, 2024-03-25)
1. Temporary rivers (TRs) have been largely overlooked in conservation assessments. Because TRs are such dynamic ecosystems, spatial and temporal aspects of their hydrology and ecology need to be taken ...
Food determines ephemerous and non-stable gut microbiome communities in juvenile wild and farmed Mediterranean fish
(Elsevier, 2023-05-16)
Novel insights were provided by contrasting the composition of wild and farmed fish gut microbiomes because the latter had essentially different environmental conditions from those in the wild. This was ...
Schlafen 12 restricts HIV-1 latency reversal by a codon-usage dependent post-transcriptional block in CD4+ T cells
(Nature Research, 2023-05-10)
Latency is a major barrier towards virus elimination in HIV-1-infected individuals. Yet, the mechanisms that contribute to the maintenance of HIV-1 latency are incompletely understood. Here we describe ...
Modelling the spatial risk of malaria through probability distribution of Anopheles maculipennis s.l. and imported cases
(Taylor and Francis, 2024-05-02)
Malaria remains one of the most important infectious diseases globally due to its high incidence and mortality rates. The
influx of infected cases from endemic to non-endemic malaria regions like Europe ...
A Protein Misfolding Shaking Amplificationbased method for the spontaneous generation of hundreds of bona fide prions
(Nature Research, 2024-03-08)
Prion diseases are a group of rapidly progressing neurodegenerative disorders
caused by the misfolding of the endogenous prion protein (PrPC) into a
pathogenic form (PrPSc). This process, despite being ...
Neurohypophysial and paracrine vasopressinergic signaling regulates aquaporin trafficking to hydrate marine teleost oocytes
(Frontiers, 2023-08-11)
The dual aquaporin (Aqp1ab1/Aqp1ab2)-mediated hydration of marine teleost eggs, which occurs during oocyte meiosis resumption (maturation), is considered a key adaptation underpinning their evolutionary ...
Changes in cortisol and cortisone in hair of pigs reared under heat stress conditions
(Frontiers Media, 2023-07-18)
Heat stress accounts for millions of dollars in losses for swine producers
worldwide. The aim of the present study was to determine and evaluate cortisol
and cortisone in hair as indicators of thermal ...