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Infravec2 guidelines for the design and operation of containment level 2 and 3 insectaries in Europe
(Taylor and Francis Group, 2022-08-22)
With the current expansion of vector-based research and an increasing number of facilities rearing arthropod vectors and infecting them with pathogens, common measures for containment of arthropods as ...
Retrospective assessment of porcine circovirus 3 (PCV-3) in formalin-fixed, paraffin-embedded tissues from pigs affected by different clinical-pathological conditions
(BioMed Central, 2022-12-05)
Background
Porcine circovirus 3 (PCV-3) is a recently discovered pathogen of swine that has been associated with several conditions. However, many questions remain unanswered regarding its infection, ...
A proof‑of‑concept study to investigate the efficacy of heat‑inactivated autovaccines in Mycobacterium caprae experimentally challenged goats
(Nature Research, 2022-12-22)
This study aimed to assess the efficacy of a heat-inactivated Mycobacterium caprae (HIMC) vaccine in goats experimentally challenged with the same strain of M. caprae. Twenty-one goats were divided into ...
Undifferentiated Wing Sarcoma in a Peach-Faced Lovebird (Agapornis roseicollis)
(Elsevier, 2022-11-04)
A 10-year-old peach-faced lovebird (Agapornis roseicollis) was evaluated for an ulcerated and painful mass at the location of a fracture 2 years previously. Whole body radiographs showed a humeral ...
Revealing Genomic Insights of the Unexplored Porcine Pathogen Actinobacillus pleuropneumoniae Using Whole Genome Sequencing
(American Society for Microbiology, 2022-07-20)
Actinobacillus pleuropneumoniae (APP) is the causative agent of pleuropneumonia in pigs, one of the most relevant bacterial respiratory diseases in the swine industry. To date, 19 serotypes have been ...
The FlagT4G Vaccine Confers a Strong and Regulated Immunity and Early Virological Protection against Classical Swine Fever
(MDPI, 2022-09-02)
Control of classical swine fever virus (CSFV) in endemic countries relies on vaccination, mostly using vaccines that do not allow for differentiation of vaccinated from infected animals (DIVA). FlagT4G ...
Clinical course impacts early kinetics,magnitude, and amplitude of SARS-CoV-2 neutralizing antibodies beyond 1 year after infection
(Cell Press, 2022-01-24)
To understand the determinants of long-term immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the concurrent impact of vaccination and emerging variants, we follow a ...
Cross-protection against African swine fever virus upon intranasal vaccination is associated with an adaptive-innate immune crosstalk
(Public Library of Science, 2022-11-09)
African swine fever virus (ASFV) is causing a worldwide pandemic affecting the porcine industry and leading to important global economic consequences. The virus causes a highly lethal hemorrhagic disease ...
Preclinical and randomized phase I studies of plitidepsin in adults hospitalized with COVID-19
(Life Science Alliance, 2022-01-10)
Plitidepsin, a marine-derived cyclic-peptide, inhibits SARS-CoV-2 replication at nanomolar concentrations by targeting the host protein eukaryotic translation elongation factor 1A. Here, we show that ...
Kinetics of immune responses elicited after three mRNA COVID-19 vaccine doses in predominantly antibody-deficient individuals
(Cell Press, 2022-10-28)
Mass vaccination campaigns reduced COVID-19 incidence and severity. Here, we evaluated the immune responses developed in SARS-CoV-2-uninfected patients with predominantly antibody-deficiencies (PAD) ...