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Efficacy of parenteral vaccination against tuberculosis with heat-inactivated Mycobacterium bovis in experimentally challenged goats
dc.contributor.author | Villegas, Claudia Arrieta | |
dc.contributor.author | Perálvarez, Tania | |
dc.contributor.author | Vidal, Enric | |
dc.contributor.author | Puighibe, Zoë | |
dc.contributor.author | Moll, Xavier | |
dc.contributor.author | Canturri, Albert | |
dc.contributor.author | Sevilla, Iker A. | |
dc.contributor.author | Espada, Yvonne | |
dc.contributor.author | Juste, Ramón A. | |
dc.contributor.author | Domingo, Mariano | |
dc.contributor.author | Pérez de Val, Bernat | |
dc.contributor.other | Producció Animal | ca |
dc.date.accessioned | 2018-11-07T16:58:31Z | |
dc.date.available | 2018-11-07T16:58:31Z | |
dc.date.issued | 2018-05-09 | |
dc.identifier.citation | Arrieta-Villegas, C., Perálvarez, T., Vidal, E., Puighibet, Z., Moll, X., Canturri, A., Sevilla, I. A., Espada, Y., Juste, R. A., Domingo, M., … Pérez de Val, B. (2018). Efficacy of parenteral vaccination against tuberculosis with heat-inactivated Mycobacterium bovis in experimentally challenged goats. PloS one, 13(5), e0196948. doi:10.1371/journal.pone.0196948 | ca |
dc.identifier.issn | 1932-6203 | ca |
dc.identifier.uri | http://hdl.handle.net/20.500.12327/63 | |
dc.description.abstract | Tuberculosis (TB) in animals is a re-emerging disease with a wide range of hosts that causes large economic losses in livestock. Goats are particularly susceptible to TB and, in endemic areas, vaccination may be a valuable measure to control the disease. The main aim of this study was to evaluate the efficacy of parenteral vaccination of goats with a heatinactivated Mycobacterium bovis (HIMB) vaccine, and compare it to M. bovis Bacille Calmette–Gue ´rin (BCG) vaccine. Twenty-four goat kids were divided in 3 groups as following: HIMB vaccinated group (n = 8), BCG vaccinated group (n = 8) and unvaccinated group (n = 8). Afterwards, goats were experimentally challenged with Mycobacterium caprae by the endobronchial route. Antigen specific interferon-γ release assays and serology were performed after vaccination and challenge. Pathological and bacteriological parameters were evaluated after necropsy at 9 weeks post-challenge (p.c.). HIMB vaccine showed similar levels of protection to BCG in terms of volume reduction of thoracic TB lesions, presence of extra-pulmonary lesions, as well as a slight reduction of bacterial load in pulmonary lymph nodes. Moreover, HIMB vaccine did not induce interferences on the interferon-γ release assay based on reagents previously developed to differentiate infected from BCG vaccinated individuals. The results indicate that HIMB is a suitable vaccine candidate for further larger-scale trials under field conditions in goats. | ca |
dc.format.extent | 14 | ca |
dc.language.iso | eng | ca |
dc.publisher | Public Library of Science | ca |
dc.relation.ispartof | PLOS One | ca |
dc.rights | Attribution 4.0 International | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.title | Efficacy of parenteral vaccination against tuberculosis with heat-inactivated Mycobacterium bovis in experimentally challenged goats | ca |
dc.type | info:eu-repo/semantics/article | ca |
dc.description.version | info:eu-repo/semantics/publishedVersion | ca |
dc.rights.accessLevel | info:eu-repo/semantics/openAccess | |
dc.embargo.terms | cap | ca |
dc.relation.projectID | INIA-FEDER/Programa Estatal de I+D+I orientada a los retos de la sociedad/RTA2015-0043-C02-01/ES/Estudio de vacunas, estrategias de vacunación y nuevas herramientas de lucha frente a la tuberculosis en la especie caprina: Estrategia DIVA/ | |
dc.subject.udc | 619 | ca |
dc.identifier.doi | https://doi.org/10.1371/journal.pone.0196948 | ca |
dc.contributor.group | Sanitat Animal | ca |
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