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Blocking transmission of Middle East respiratory syndrome coronavirus (MERS-CoV) in llamas by vaccination with a recombinant spike protein
dc.contributor.author | Rodon, Jordi | |
dc.contributor.author | Okba, Nisreen M. A. | |
dc.contributor.author | Te, Nigeer | |
dc.contributor.author | van Dieren, Brenda | |
dc.contributor.author | Bosch, Berend-Jan | |
dc.contributor.author | Bensaid, Albert | |
dc.contributor.author | Segalés, Joaquim | |
dc.contributor.author | Haagmans, Bart L. | |
dc.contributor.author | Vergara-Alert, Júlia | |
dc.contributor.other | Producció Animal | ca |
dc.date.accessioned | 2020-04-16T14:31:00Z | |
dc.date.available | 2020-04-16T14:31:00Z | |
dc.date.issued | 2019-11-12 | |
dc.identifier.citation | Rodon, Jordi, Nisreen M. A. Okba, Nigeer Te, Brenda van Dieren, Berend-Jan Bosch, Albert Bensaid, Joaquim Segalés, Bart L. Haagmans, and Júlia Vergara-Alert. 2019. "Blocking Transmission Of Middle East Respiratory Syndrome Coronavirus (MERS-Cov) In Llamas By Vaccination With A Recombinant Spike Protein". Emerging Microbes & Infections 8 (1): 1593-1603. Informa UK Limited. doi:10.1080/22221751.2019.1685912. | ca |
dc.identifier.issn | 2222-1751 | ca |
dc.identifier.uri | http://hdl.handle.net/20.500.12327/692 | |
dc.description.abstract | The ongoing Middle East respiratory syndrome coronavirus (MERS-CoV) outbreaks pose a worldwide public health threat. Blocking MERS-CoV zoonotic transmission from dromedary camels, the animal reservoir, could potentially reduce the number of primary human cases. Here we report MERS-CoV transmission from experimentally infected llamas to naïve animals. Directly inoculated llamas shed virus for at least 6 days and could infect all in-contact naïve animals 4-5 days after exposure. With the aim to block virus transmission, we examined the efficacy of a recombinant spike S1-protein vaccine. In contrast to naïve animals, in-contact vaccinated llamas did not shed infectious virus upon exposure to directly inoculated llamas, consistent with the induction of strong virus neutralizing antibody responses. Our data provide further evidence that vaccination of the reservoir host may impede MERS-CoV zoonotic transmission to humans. | ca |
dc.format.extent | 12 | ca |
dc.language.iso | eng | ca |
dc.publisher | Taylor & Francis Open | ca |
dc.relation.ispartof | Emerging Microbes and Infections | ca |
dc.rights | Attribution 4.0 International | ca |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.title | Blocking transmission of Middle East respiratory syndrome coronavirus (MERS-CoV) in llamas by vaccination with a recombinant spike protein | ca |
dc.type | info:eu-repo/semantics/article | ca |
dc.description.version | info:eu-repo/semantics/publishedVersion | ca |
dc.rights.accessLevel | info:eu-repo/semantics/openAccess | |
dc.embargo.terms | cap | ca |
dc.relation.projectID | EC/PF7/115760/EU/Zoonotic Anticipation and Preparedness Initiative/ZAPI | ca |
dc.relation.projectID | EC/H2020/731014/EU/Veterinary Biocontained facility Network for excellence in animal infectiology research and experimentation /VetBioNet | ca |
dc.subject.udc | 619 | ca |
dc.identifier.doi | https://doi.org/10.1080/22221751.2019.1685912 | ca |
dc.contributor.group | Sanitat Animal | ca |
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