Efect of feed restriction on the environmental variability of birth weight in divergently selected lines of mice
Sánchez, Juan Pablo
Gutiérrez, Juan Pablo
Selection of mice for decreased environmental variability of birth weight has achieved higher survivability and larger litter size as a correlated response to canalized selection, which suggests higher welfare and robustness, and animals that are more homogeneous. However, in these studies, animals were not exposed to an environmental challenge. To demonstrate the advantages of this mouse line with a low environmental variability of birth weight, animals from two divergent lines (high and low variability of birth weight) were subjected to feed restriction. The objective of this study was to use these divergent lines to compare their response in terms of robustness against an environmental challenge. At weaning, 120 females, i.e. four full-sib females from 10 random litters of three consecutive generations of selection, were chosen from these divergent lines. The total number of females was divided into four groups, which were subjected to a feeding regimen by imposing different levels of feed restriction (i.e. 75, 90 and 85% of full ad libitum feed across three generations, respectively) in different combinations during the growth and reproduction periods.
575 - Genètica general. Citogenètica general. Immunogenètica. Evolució. Filogènia
Is part of
Genetics Selection Evolution
Formoso-Rafferty, Nora, Isabel Cervantes, Juan Pablo Sánchez, Juan Pablo Gutiérrez, and Loys Bodin. 2019. "Effect Of Feed Restriction On The Environmental Variability Of Birth Weight In Divergently Selected Lines Of Mice". Genetics Selection Evolution 51 (1). doi:10.1186/s12711-019-0471-9.
Grant agreement number
EC/H2020/633531/EU/Adapting the feed, the animal and the feeding techniques to improve the efficiency and sustainability of monogastric livestock production systems/Feed-a-Gene
INIA/Programa Estatal de I+D+I orientada a los retos de la sociedad/RTA2014‑00015‑C02‑02/ES/Selección ponderada divergente para el carácter variabilidad ambiental del peso al nacimiento en ratones. Relación entre la homogeneidad y la eficiencia/
Genètica i Millora Animal
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