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dc.contributor.authorBallester, Maria
dc.contributor.authorQuintanilla, Raquel
dc.contributor.authorOrtega, Francisco J.
dc.contributor.authorSerrano, José C. E.
dc.contributor.authorCassanyé, Anna
dc.contributor.authorRodríguez-Palmero, Maria
dc.contributor.authorMoreno-Muñoz, José A.
dc.contributor.authorPortero-Otin, Manuel
dc.contributor.authorTibau, Joan
dc.contributor.otherProducció Animalca
dc.date.accessioned2020-04-27T05:33:21Z
dc.date.available2020-04-27T05:33:21Z
dc.date.issued2020-03-25
dc.identifier.citationBallester, Maria, Raquel Quintanilla, Francisco J. Ortega, José C. E. Serrano, Anna Cassanyé, Maria Rodríguez-Palmero, José A. Moreno-Muñoz, Manuel Portero-Otin, and Joan Tibau. 2020. "Dietary Intake Of Bioactive Ingredients Impacts Liver And Adipose Tissue Transcriptomes In A Porcine Model Of Prepubertal Early Obesity". Scientific Reports 10 (1). Springer Science and Business Media LLC. doi:10.1038/s41598-020-62320-4.ca
dc.identifier.issn2045-2322ca
dc.identifier.urihttp://hdl.handle.net/20.500.12327/742
dc.description.abstractGlobal prevalence of obesity has increased to epidemic proportions over the past 40 years, with childhood obesity reaching alarming rates. In this study, we determined changes in liver and adipose tissue transcriptomes of a porcine model for prepubertal early obesity induced by a high-calorie diet and supplemented with bioactive ingredients. A total of 43 nine-weeks-old animals distributed in four pens were fed with four different dietary treatments for 10 weeks: a conventional diet; a western-type diet; and a western-type diet with Bifidobacterium breve and rice hydrolysate, either adding or not omega-3 fatty acids. Animals fed a western-type diet increased body weight and total fat content and exhibited elevated serum concentrations of cholesterol, whereas animals supplemented with bioactive ingredients showed lower body weight gain and tended to accumulate less fat. An RNA-seq experiment was performed with a total of 20 animals (five per group). Differential expression analyses revealed an increase in lipogenesis, cholesterogenesis and inflammatory processes in animals on the western-type diet while the supplementation with bioactive ingredients induced fatty acid oxidation and cholesterol catabolism, and decreased adipogenesis and inflammation. These results reveal molecular mechanisms underlying the beneficial effects of bioactive ingredient supplementation in an obese pig model.ca
dc.format.extent14ca
dc.language.isoengca
dc.publisherNature Researchca
dc.relation.ispartofScientific Reportsca
dc.rightsAttribution 4.0 Internationalca
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleDietary intake of bioactive ingredients impacts liver and adipose tissue transcriptomes in a porcine model of prepubertal early obesityca
dc.typeinfo:eu-repo/semantics/articleca
dc.description.versioninfo:eu-repo/semantics/publishedVersionca
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.termscapca
dc.relation.projectIDMINECO/Programa Estatal de promoción del talento y su empleabilidad en I+D+I/RYC‑2013‑12573/ES/ /ca
dc.subject.udc619ca
dc.identifier.doihttps://doi.org/10.1038/s41598-020-62320-4ca
dc.contributor.groupGenètica i Millora Animalca


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Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/