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dc.contributor.authorLidón, Laia
dc.contributor.authorUrrea, Laura
dc.contributor.authorLlorens, Franc
dc.contributor.authorGil, Vanessa
dc.contributor.authorAlvarez, Ignacio
dc.contributor.authorDiez-Fairen, Monica
dc.contributor.authorAguilar, Miguel
dc.contributor.authorPastor, Pau
dc.contributor.authorZerr, Inga
dc.contributor.authorAlcolea, Daniel
dc.contributor.authorLleó, Alberto
dc.contributor.authorVidal, Enric
dc.contributor.authorGavín, Rosalina
dc.contributor.authorFerrer, Isidre
dc.contributor.authorDel Rio, Jose Antonio
dc.contributor.otherProducció Animalca
dc.date.accessioned2020-06-02T06:18:32Z
dc.date.available2020-06-02T06:18:32Z
dc.date.issued2020-05-19
dc.identifier.citationLidón, Laia, Laura Urrea, Franc Llorens, Vanessa Gil, Ignacio Alvarez, Monica Diez-Fairen, and Miguel Aguilar et al. 2020. "Disease-Specific Changes In Reelin Protein And Mrna In Neurodegenerative Diseases". Cells 9 (5): 1252. MDPI AG. doi:10.3390/cells9051252.ca
dc.identifier.issn2073-4409ca
dc.identifier.urihttp://hdl.handle.net/20.500.12327/839
dc.description.abstractReelin is an extracellular glycoprotein that modulates neuronal function and synaptic plasticity in the adult brain. Decreased levels of Reelin activity have been postulated as a key factor during neurodegeneration in Alzheimer´s disease (AD) and in aging. Thus, changes in levels of full-length Reelin and Reelin fragments have been revealed in cerebrospinal fluid (CSF) and in post-mortem brains samples of AD patients with respect to non-AD patients. However, conflicting studies have reported decreased or unchanged levels of full-length Reelin in AD patients compared to control (nND) cases in post-mortem brains and CSF samples. In addition, a compelling analysis of Reelin levels in neurodegenerative diseases other than AD is missing. In this study, we analyzed brain levels of RELN mRNA and Reelin protein in post-mortem frontal cortex samples from different sporadic AD stages, Parkinson's disease with dementia (PDD), and Creutzfeldt-Jakob disease (sCJD), obtained from five different Biobanks. In addition, we measured Reelin protein levels in CSF samples of patients with mild cognitive impairment (MCI), dementia, or sCJD diagnosis and a group of neurologically healthy cases. The results indicate an increase in RELN mRNA in the frontal cortex of advanced stages of AD and in sCJD(I) compared to controls. This was not observed in PDD and early AD stages. However, Reelin protein levels in frontal cortex samples were unchanged between nND and advanced AD stages and PDD. Nevertheless, they decreased in the CSF of patients with dementia in comparison to those not suffering with dementia and patients with MCI. With respect to sCJD, there was a tendency to increase in brain samples in comparison to nND and to decrease in the CSF with respect to nND. In conclusion, Reelin levels in CSF cannot be considered as a diagnostic biomarker for AD or PDD. However, we feel that the CSF Reelin changes observed between MCI, patients with dementia, and sCJD might be helpful in generating a biomarker signature in prodromal studies of unidentified dementia and sCJD.ca
dc.format.extent18ca
dc.language.isoengca
dc.publisherMDPIca
dc.relation.ispartofCellsca
dc.rightsAttribution 4.0 Internationalca
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleDisease-specific changes in reelin protein and mRNA in neurodegenerative diseasesca
dc.typeinfo:eu-repo/semantics/articleca
dc.description.versioninfo:eu-repo/semantics/publishedVersionca
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.termscapca
dc.relation.projectIDMCIU-AEI-FEDER/Programa estatal de I+D+i orientada a los retos de la sociedad/RTI2018-099773-B-I00/ES/NUEVAS APROXIMACIONES PARA ENTENDER LAS FUNCIONES DE LA PRPC Y MIEMBROS SECRETABLES DE SEMAFORINAS DURANTE EL DESARROLLO DEL HIPOCAMPO Y EN NEUROTRANSMISION/ca
dc.subject.udc619ca
dc.identifier.doihttps://doi.org/10.3390/cells9051252ca
dc.contributor.groupSanitat Animalca


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Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/