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dc.contributor.authorParma, Valentina
dc.contributor.authorOhla, Kathrin
dc.contributor.authorVeldhuizen, Maria G.
dc.contributor.authorNiv, Masha Y.
dc.contributor.authorKelly, Christine E.
dc.contributor.authorBakke, Alyssa J.
dc.contributor.authorCooper, Keiland W.
dc.contributor.authorBouysset, Cédric
dc.contributor.authorPirastu, Nicola
dc.contributor.authorDibattista, Michele
dc.contributor.authorGuàrdia, Maria Dolors
dc.contributor.otherIndústries Alimentàriesca
dc.date.accessioned2020-07-20T07:13:19Z
dc.date.issued2020-06-20
dc.identifier.citationParma, Valentina, Kathrin Ohla, Maria G Veldhuizen, Masha Y Niv, Christine E Kelly, Alyssa J Bakke, and Keiland W Cooper et al. 2020. "More Than Smell – COVID-19 Is Associated With Severe Impairment Of Smell, Taste, And Chemesthesis". Chemical Senses. doi:10.1093/chemse/bjaa041.ca
dc.identifier.issn0379-864Xca
dc.identifier.urihttp://hdl.handle.net/20.500.12327/874
dc.description.abstractRecent anecdotal and scientific reports have provided evidence of a link between COVID-19 and chemosensory impairments such as anosmia. However, these reports have downplayed or failed to distinguish potential effects on taste, ignored chemesthesis, and generally lacked quantitative measurements. Here, we report the development, implementation and initial results of a multi-lingual, international questionnaire to assess self-reported quantity and quality of perception in three distinct chemosensory modalities (smell, taste, and chemesthesis) before and during COVID-19. In the first 11 days after questionnaire launch, 4039 participants (2913 women, 1118 men, 8 other, ages 19-79) reported a COVID-19 diagnosis either via laboratory tests or clinical assessment. Importantly, smell, taste and chemesthetic function were each significantly reduced compared to their status before the disease. Difference scores (maximum possible change ±100) revealed a mean reduction of smell (-79.7 ± 28.7, mean ± SD), taste (-69.0 ± 32.6), and chemesthetic (-37.3 ± 36.2) function during COVID-19. Qualitative changes in olfactory ability (parosmia and phantosmia) were relatively rare and correlated with smell loss. Importantly, perceived nasal obstruction did not account for smell loss. Furthermore, chemosensory impairments were similar between participants in the laboratory test and clinical assessment groups. These results show that COVID-19-associated chemosensory impairment is not limited to smell, but also affects taste and chemesthesis. The multimodal impact of COVID-19 and lack of perceived nasal obstruction suggest that SARS-CoV-2 infection may disrupt sensory-neural mechanisms.ca
dc.format.extent45ca
dc.language.isoengca
dc.publisherOxford University Pressca
dc.relation.ispartofChemical Sensesca
dc.rights© The Author(s) 2020ca
dc.titleMore than smell - COVID-19 is associated with severe impairment of smell, taste, and chemesthesisca
dc.typeinfo:eu-repo/semantics/articleca
dc.description.versioninfo:eu-repo/semantics/acceptedVersionca
dc.rights.accessLevelinfo:eu-repo/semantics/embargoedAccess
dc.date.embargoEnd2021-06-20T02:00:00Z
dc.embargo.terms12 mesosca
dc.subject.udc663/664ca
dc.identifier.doihttps://doi.org/10.1093/chemse/bjaa041ca
dc.contributor.groupQualitat i Tecnologia Alimentàriaca


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