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dc.contributor.authorGifre-Renom, L.
dc.contributor.authorCarratalá, J. V.
dc.contributor.authorParés, S.
dc.contributor.authorSánchez-García, L.
dc.contributor.authorFerrer-Miralles, N.
dc.contributor.authorVillaverde, A.
dc.contributor.authorBach, A.
dc.contributor.authorGarcia-Fruitós, Elena
dc.contributor.authorArís, Anna
dc.contributor.otherProducció Animalca
dc.date.accessioned2020-07-27T08:49:58Z
dc.date.available2020-07-27T08:49:58Z
dc.date.issued2020-07-09
dc.identifier.citationGifre-Renom, L., J. V. Carratalá, S. Parés, L. Sánchez-García, N. Ferrer-Miralles, A. Villaverde, A. Bach, Elena Garcia-Fruitós, and Anna Arís. 2020. "Potential Of MMP-9 Based Nanoparticles At Optimizing The Cow Dry Period: Pulling Apart The Effects Of MMP-9 And Nanoparticles". Scientific Reports 10 (1). doi:10.1038/s41598-020-67176-2.ca
dc.identifier.issn2045-2322ca
dc.identifier.urihttp://hdl.handle.net/20.500.12327/875
dc.description.abstractThe cow dry period is a non-milking interval where the mammary gland involutes and regenerates to guarantee an optimal milk production in the subsequent lactation. Important bottlenecks such as the high risk of intramammary infections complicate the process. Antibiotics have been routinely used as a preventive treatment but the concerns about potential antibiotic resistance open a new scenario in which alternative strategies have to be developed. Matrix metalloproteinase-9 (MMP-9) is an enzyme able to degrade the extracellular matrix, triggering the involution and immune function of cow mammary gland. We have studied the infusion into the mammary gland of MMP-9 inclusion bodies as protein-based nanoparticles, demonstrating that 1.2 mg of MMP-9 enhanced the involution and immune function of the cow mammary gland. However, the comparison of the efects triggered by the administration of an active and an inactive form of MMP-9 led to conclude that the response observed in the bovine mammary gland was mainly due to the protein format but not to the biological activity of the MMP-9 embedded in the inclusion body. This study provides relevant information on the future use of protein inclusion bodies in cow mammary gland and the role of MMP-9 at dry-of.ca
dc.format.extent8ca
dc.language.isoengca
dc.publisherNature Researchca
dc.relation.ispartofScientific Reportsca
dc.rightsAttribution 4.0 Internationalca
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titlePotential of MMP-9 based nanoparticles at optimizing the cow dry period: pulling apart the effects of MMP-9 and nanoparticlesca
dc.typeinfo:eu-repo/semantics/articleca
dc.description.versioninfo:eu-repo/semantics/publishedVersionca
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.termscapca
dc.relation.projectIDINIA/Programa Nacional de Proyectos de Investigación Fundamental/RTA2012-00028-C02-01/ES/Optimización del periodo de secado de la vaca mediante nanopartículas proteicas/ca
dc.relation.projectIDINIA/Programa Nacional de Proyectos de Investigación Fundamental/RTA2012-00028-C02-02/ES/Optimización del periodo de secado de la vaca mediante nanopartículas proteicas/ca
dc.relation.projectIDINIA/Programa Estatal de I+D+I orientada a los retos de la Sociedad/RTA2015-00064-C02-01/ES/Validación del uso de las proteínas M-SAA3 y MMP-9 en la mejora del secado de la vaca de leche y optimización de su dosis efectiva mediante su nanoestructuración/ca
dc.relation.projectIDINIA/Programa Estatal de I+D+I orientada a los retos de la Sociedad/RTA2015-00064-C02-02/ES/Validación del uso de las proteínas M-SAA3 y MMP-9 en la mejora del secado de la vaca de leche y optimización de su dosis efectiva mediante su nanoestructuración/ca
dc.subject.udc619ca
dc.subject.udc636ca
dc.identifier.doihttps://doi.org/10.1038/s41598-020-67176-2ca
dc.contributor.groupProducció de Remugantsca


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