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dc.contributor.authorBovo, S.
dc.contributor.authorRibani, A.
dc.contributor.authorMuñoz, M.
dc.contributor.authorAlves, E.
dc.contributor.authorAraujo, J. P.
dc.contributor.authorBozzi, R.
dc.contributor.authorCharneca, R.
dc.contributor.authorDi Palma, F.
dc.contributor.authorEtherington, G.
dc.contributor.authorFernandez, A. I.
dc.contributor.authorGarcía, F.
dc.contributor.authorGarcía‐Casco, J.
dc.contributor.authorKarolyi, D.
dc.contributor.authorGallo, M.
dc.contributor.authorGvozdanović, K.
dc.contributor.authorMartins, J. M.
dc.contributor.authorMercat, M. J.
dc.contributor.authorNúñez, Y.
dc.contributor.authorQuintanilla, R.
dc.contributor.authorRadović, Č.
dc.contributor.authorRazmaite, V.
dc.contributor.authorRiquet, J.
dc.contributor.authorSavić, R.
dc.contributor.authorSchiavo, G.
dc.contributor.authorŠkrlep, M.
dc.contributor.authorUsai, G.
dc.contributor.authorUtzeri, V. J.
dc.contributor.authorZimmer, C.
dc.contributor.authorOvilo, C.
dc.contributor.authorFontanesi, L.
dc.contributor.otherProducció Animalca
dc.date.accessioned2020-10-08T13:36:50Z
dc.date.issued2020-06-08
dc.identifier.citationBovo, S., A. Ribani, M. Muñoz, E. Alves, J. P. Araujo, R. Bozzi, and R. Charneca et al. 2020. "Genome‐Wide Detection Of Copy Number Variants In European Autochthonous And Commercial Pig Breeds By Whole‐Genome Sequencing Of DNA Pools Identified Breed‐Characterising Copy Number States". Animal Genetics. doi:10.1111/age.12954.ca
dc.identifier.issn0268-9146ca
dc.identifier.urihttp://hdl.handle.net/20.500.12327/916
dc.description.abstractIn this study, we identified copy number variants (CNVs) in 19 European autochthonous pig breeds and in two commercial breeds (Italian Large White and Italian Duroc) that represent important genetic resources for this species. The genome of 725 pigs was sequenced using a breed‐specific DNA pooling approach (30–35 animals per pool) obtaining an average depth per pool of 42×. This approach maximised CNV discovery as well as the related copy number states characterising, on average, the analysed breeds. By mining more than 17.5 billion reads, we identified a total of 9592 CNVs (~683 CNVs per breed) and 3710 CNV regions (CNVRs; 1.15% of the reference pig genome), with an average of 77 CNVRs per breed that were considered as private. A few CNVRs were analysed in more detail, together with other information derived from sequencing data. For example, the CNVR encompassing the KIT gene was associated with coat colour phenotypes in the analysed breeds, confirming the role of the multiple copies in determining breed‐specific coat colours. The CNVR covering the MSRB3 gene was associated with ear size in most breeds. The CNVRs affecting the ELOVL6 and ZNF622 genes were private features observed in the Lithuanian Indigenous Wattle and in the Turopolje pig breeds respectively. Overall, the genome variability unravelled here can explain part of the genetic diversity among breeds and might contribute to explain their origin, history and adaptation to a variety of production systems.ca
dc.format.extent44ca
dc.language.isoengca
dc.publisherWileyca
dc.relation.ispartofAnimal Geneticsca
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalca
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleGenome‐wide detection of copy number variants in European autochthonous and commercial pig breeds by whole‐genome sequencing of DNA pools identified breed‐characterising copy number statesca
dc.typeinfo:eu-repo/semantics/articleca
dc.description.versioninfo:eu-repo/semantics/acceptedVersionca
dc.rights.accessLevelinfo:eu-repo/semantics/embargoedAccess
dc.date.embargoEnd2021-06-08T02:00:00Z
dc.embargo.terms12 mesosca
dc.relation.projectIDEC/H2020/634476/EU/Diversity of local pig breeds and production systems for high quality traditional products and sustainable pork chains/TREASUREca
dc.relation.projectIDEC/COST/CA15112/EU/Functional Annotation of Animal Genomes-European network/FAANG-Europeca
dc.subject.udc577ca
dc.subject.udc59ca
dc.subject.udc619ca
dc.subject.udc636ca
dc.identifier.doihttps://doi.org/10.1111/age.12954ca
dc.contributor.groupGenètica i Millora Animalca


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