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dc.contributor.authorCriado-Mesas, Lourdes
dc.contributor.authorBallester, Maria
dc.contributor.authorCrespo-Piazuelo, Daniel
dc.contributor.authorCastelló, Anna
dc.contributor.authorFernández, Ana I.
dc.contributor.authorFolch, Josep M.
dc.contributor.otherProducció Animalca
dc.date.accessioned2020-10-14T12:43:36Z
dc.date.available2020-10-14T12:43:36Z
dc.date.issued2020-06-17
dc.identifier.citationCriado-Mesas, Lourdes, Maria Ballester, Daniel Crespo-Piazuelo, Anna Castelló, Ana I. Fernández, and Josep M. Folch. 2020. "Identification Of Eqtls Associated With Lipid Metabolism In Longissimus Dorsi Muscle Of Pigs With Different Genetic Backgrounds". Scientific Reports 10 (1). doi:10.1038/s41598-020-67015-4.ca
dc.identifier.issn2045-2322ca
dc.identifier.urihttp://hdl.handle.net/20.500.12327/920
dc.description.abstractIntramuscular fat content and its fatty acid composition affect porcine meat quality and its nutritional value. The present work aimed to identify genomic variants regulating the expression in the porcine muscle (Longissimus dorsi) of 45 candidate genes for lipid metabolism and fatty acid composition in three experimental backcrosses based on the Iberian breed. Expression genome-wide association studies (eGWAS) were performed between the muscle gene expression values, measured by real-time quantitative PCR, and the genotypes of 38,426 SNPs distributed along all chromosomes. The eGWAS identified 186 eSNPs located in ten Sus scrofa regions and associated with the expression of ACSM5, ACSS2, ATF3, DGAT2, FOS and IGF2 (FDR < 0.05) genes. Two expression quantitative trait loci (eQTLs) for IGF2 and ACSM5 were classified as cis-acting eQTLs, suggesting a mutation in the same gene affecting its expression. Conversely, ten eQTLs showed trans-regulatory effects on gene expression. When the eGWAS was performed for each backcross independently, only three common trans-eQTL regions were observed, indicating different regulatory mechanisms or allelic frequencies among the breeds. In addition, hotspot regions regulating the expression of several genes were detected. Our results provide new data to better understand the functional regulatory mechanisms of lipid metabolism genes in muscle.ca
dc.format.extent13ca
dc.language.isoengca
dc.publisherNature Researchca
dc.relation.ispartofScientific Reportsca
dc.rightsAttribution 4.0 Internationalca
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleIdentification of eQTLs associated with lipid metabolism in Longissimus dorsi muscle of pigs with different genetic backgroundsca
dc.typeinfo:eu-repo/semantics/articleca
dc.description.versioninfo:eu-repo/semantics/publishedVersionca
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.termscapca
dc.relation.projectIDMINECO-FEDER/Programa estatal de I+D+I orientada a los retos de la sociedad/AGL2014-56369-C2-2-R/ES//Validación genética y funcional de QTLS, genes y redes génicas y estudio del efecto del microbioma sobre crecimiento, deposición de grasa y calidad de carne en porcino. S2/ca
dc.relation.projectIDMINECO-FEDER/Programa Estatal de I+D+I orientada a los retos de la sociedad/AGL2017-82641-R/ES/Genómica funcional, biología de sistemas y microbiomica aplicadas a la identificación de reguladores genéticos del crecimiento, engrasamiento y calidad de la carne en porcino/ca
dc.relation.projectIDMINECO/Programa Estatal de promoción del talento y su empleabilidad en I+D+I/RYC‑2013‑12573/ES/ /ca
dc.relation.projectIDMINECO/Programa Estatal de fomento de la investigación científica y técnica de excelencia/SEV-2015-0533/ES/ /ca
dc.subject.udc57ca
dc.subject.udc573ca
dc.subject.udc575ca
dc.subject.udc59ca
dc.subject.udc619ca
dc.subject.udc636ca
dc.identifier.doihttps://doi.org/10.1038/s41598-020-67015-4ca
dc.contributor.groupGenètica i Millora Animalca


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