Identification of strong candidate genes for backfat and intramuscular fatty acid composition in three crosses based on the Iberian pig
Noguera, José L.
Fernández, Ana I.
Folch, Josep M.
Meat quality has an important genetic component and can be modified by the fatty acid (FA) composition and the amount of fat contained in adipose tissue and muscle. The present study aimed to find genomic regions associated with the FA composition in backfat and muscle (longissimus dorsi) in 439 pigs with three different genetic backgrounds but having the Iberian breed in common. Genome-wide association studies (GWAS) were performed between 38,424 single-nucleotide polymorphisms (SNPs) covering the pig genome and 60 phenotypic traits related to backfat and muscle FA composition. Nine significant associated regions were found in backfat on the Sus scrofa chromosomes (SSC): SSC1, SSC2, SSC4, SSC6, SSC8, SSC10, SSC12, and SSC16. For the intramuscular fat, six significant associated regions were identified on SSC4, SSC13, SSC14, and SSC17. A total of 52 candidate genes were proposed to explain the variation in backfat and muscle FA composition traits. GWAS were also reanalysed including SNPs on five candidate genes (ELOVL6, ELOVL7, FADS2, FASN, and SCD). Regions and molecular markers described in our study may be useful for meat quality selection of commercial pig breeds, although several polymorphisms were breed-specific, and further analysis would be needed to evaluate possible causal mutations.
57 - Biological sciences in general
575 - General genetics. General cytogenetics
59 - Zoology
619 - Veterinary science
636 - Animal husbandry and breeding in general. Livestock rearing. Breeding of domestic animals
Is part of
Crespo-Piazuelo, Daniel, Lourdes Criado-Mesas, Manuel Revilla, Anna Castelló, José L. Noguera, Ana I. Fernández, Maria Ballester, and Josep M. Folch. 2020. "Identification Of Strong Candidate Genes For Backfat And Intramuscular Fatty Acid Composition In Three Crosses Based On The Iberian Pig". Scientific Reports 10 (1). doi:10.1038/s41598-020-70894-2.
Grant agreement number
MINECO-FEDER/Programa Estatal de I+D+I orientada a los retos de la sociedad/AGL2017-82641-R/ES/Genómica funcional, biología de sistemas y microbiomica aplicadas a la identificación de reguladores genéticos del crecimiento, engrasamiento y calidad de la carne en porcino/
MINECO/Programa Estatal de promoción del talento y su empleabilidad en I+D+I/RYC‑2013‑12573/ES/ /
MINECO/Programa Estatal de fomento de la investigación científica y técnica de excelencia/SEV-2015-0533/ES/ /
MINECO-FEDER/Programa Estatal de I+D+I orientada a los retos de la sociedad/AGL2014-56369-C2-2-R/ES/VALIDACION GENETICA Y FUNCIONAL DE QTLS, GENES Y REDES GENICAS Y ESTUDIO DEL EFECTO DEL MICROBIOMA EN EL CRECIMIENTO, DEPOSICION DE GRASA Y CALIDAD DE LA CARNE EN PORCINO S2/
Genètica i Millora Animal
This item appears in the following Collection(s)
- ARTICLES CIENTÍFICS 
The following license files are associated with this item:
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/