Show simple item record

dc.contributor.authorHong, Joon-Ki
dc.contributor.authorLee, Jae-Bong
dc.contributor.authorRamayo-Caldas, Yuliaxis
dc.contributor.authorKim, Si-Dong
dc.contributor.authorCho, Eun-Seok
dc.contributor.authorKim, Young-Sin
dc.contributor.authorCho, Kyu-Ho
dc.contributor.authorLee, Deuk-Hwan
dc.contributor.authorPark, Hee-Bok
dc.contributor.otherProducció Animalca
dc.date.accessioned2020-11-25T16:27:47Z
dc.date.available2020-11-25T16:27:47Z
dc.date.issued2020-09-11
dc.identifier.citationHong, Joon-Ki, Jae-Bong Lee, Yuliaxis Ramayo-Caldas, Si-Dong Kim, Eun-Seok Cho, Young-Sin Kim, Kyu-Ho Cho, Deuk-Hwan Lee, and Hee-Bok Park. 2020. "Single-Step Genome-Wide Association Study For Social Genetic Effects And Direct Genetic Effects On Growth In Landrace Pigs". Scientific Reports 10 (1). doi:10.1038/s41598-020-71647-x.ca
dc.identifier.issn2045-2322ca
dc.identifier.urihttp://hdl.handle.net/20.500.12327/989
dc.description.abstractIn livestock social interactions, social genetic effects (SGE) represent associations between phenotype of one individual and genotype of another. Such associations occur when the trait of interest is affected by transmissible phenotypes of social partners. The aim of this study was to estimate SGE and direct genetic effects (DGE, genetic effects of an individual on its own phenotype) on average daily gain (ADG) in Landrace pigs, and to conduct single-step genome-wide association study using SGE and DGE as dependent variables to identify quantitative trait loci (QTLs) and their positional candidate genes. A total of 1,041 Landrace pigs were genotyped using the Porcine SNP 60K BeadChip. Estimates of the two effects were obtained using an extended animal model. The SGE contributed 16% of the total heritable variation of ADG. The total heritability estimated by the extended animal model including both SGE and DGE was 0.52. The single-step genome-wide association study identified a total of 23 QTL windows for the SGE on ADG distributed across three chromosomes (i.e., SSC1, SSC2, and SSC6). Positional candidate genes within these QTL regions included PRDM13, MAP3K7, CNR1, HTR1E, IL4, IL5, IL13, KIF3A, EFHD2, SLC38A7, mTOR, CNOT1, PLCB2, GABRR1, and GABRR2, which have biological roles in neuropsychiatric processes. The results of biological pathway and gene network analyses also support the association of the neuropsychiatric processes with SGE on ADG in pigs. Additionally, a total of 11 QTL windows for DGE on ADG in SSC2, 3, 6, 9, 10, 12, 14, 16, and 17 were detected with positional candidate genes such as ARL15. We found a putative pleotropic QTL for both SGE and DGE on ADG on SSC6. Our results in this study provide important insights that can help facilitate a better understanding of the molecular basis of SGE for socially affected traits.ca
dc.format.extent11ca
dc.language.isoengca
dc.publisherNature Researchca
dc.relation.ispartofScientific Reportsca
dc.rightsAttribution 4.0 Internationalca
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleSingle-step genome-wide association study for social genetic effects and direct genetic effects on growth in Landrace pigsca
dc.typeinfo:eu-repo/semantics/articleca
dc.description.versioninfo:eu-repo/semantics/publishedVersionca
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.termscapca
dc.subject.udc636ca
dc.identifier.doihttps://doi.org/10.1038/s41598-020-71647-xca
dc.contributor.groupGenètica i Millora Animalca


Files in this item

 

This item appears in the following Collection(s)

Show simple item record

Attribution 4.0 International
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/