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dc.contributor.authorBiré, Ronel
dc.contributor.authorBertin, Thomas
dc.contributor.authorDom, Inès
dc.contributor.authorHort, Vincent
dc.contributor.authorSchmitt, Corinne
dc.contributor.authorDiogène, Jorge
dc.contributor.authorLemée, Rodolphe
dc.contributor.authorDe Haro, Luc
dc.contributor.authorNicolas, Marina
dc.contributor.otherAgrosistemes i Medi Ambientca
dc.date.accessioned2020-11-30T16:22:33Z
dc.date.available2020-11-30T16:22:33Z
dc.date.issued2020-05-29
dc.identifier.citationBiré, Ronel, Thomas Bertin, Inès Dom, Vincent Hort, Corinne Schmitt, Jorge Diogène, Rodolphe Lemée, Luc De Haro, and Marina Nicolas. 2020. "First Evidence Of The Presence Of Anatoxin-A In Sea Figs Associated With Human Food Poisonings In France". Marine Drugs 18 (6): 285. doi:10.3390/md18060285.ca
dc.identifier.issn1660-3397ca
dc.identifier.urihttp://hdl.handle.net/20.500.12327/991
dc.description.abstractFrom January 2011 to March 2018, 26 patients aged from 20 to 80 years old reported being sick in France after eating sea figs of the genus Microcosmus. The patients had symptoms evoking a cerebellar syndrome: blurred or double vision, ataxia and dizziness, asthenia, headache, muscle cramps, paresthesia and digestive disorders (nausea, vomiting and diarrhea). Three of the 18 food poisoning events recorded by the Poison Control Center in Marseille and involving four patients were further investigated as the meal leftovers were collected and analyzed. A previous study ruled out the presence of the regulated lipophilic marine toxins after high-resolution mass spectrometry, but further analyses were required to look for hydrophilic cyanotoxins. The sea fig leftovers from food poisoning case Numbers 1 (January 2011), 6 (December 2012) and 17 (March 2018) of this published case series were analyzed by hydrophilic interaction liquid chromatography coupled to low- and high-resolution mass spectrometry to investigate the presence of hydrophilic cyanotoxins. The sea fig samples showed anatoxin-a (ATX-a) concentrations ranging from 193.7 to 1240.2 µg/kg. The sea fig control sample analyzed was also contaminated with ATX-a but in a much smaller concentration (22.5 µg/kg). To the best of our knowledge, this is the first report of human food poisoning involving ATX-a as the possible causative toxin where the cyanotoxin could be unequivocally identified.ca
dc.format.extent14ca
dc.language.isoengca
dc.publisherMDPIca
dc.relation.ispartofMarine Drugsca
dc.rightsAttribution 4.0 Internationalca
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleFirst Evidence of the Presence of Anatoxin-A in Sea Figs Associated with Human Food Poisonings in Franceca
dc.typeinfo:eu-repo/semantics/articleca
dc.description.versioninfo:eu-repo/semantics/publishedVersionca
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.termscapca
dc.subject.udc574ca
dc.identifier.doihttps://doi.org/10.3390/md18060285ca
dc.contributor.groupAigües Marines i Continentalsca


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