Identification of a Newly Conserved SLA-II Epitope in a Structural Protein of Swine Influenza Virus
Autor/a
Baratelli, Massimiliano
Morgan, Sophie
Hemmink, Johanneke Dinie
Reid, Elizabeth
Carr, Brigid Veronica
Lefevre, Eric
Montaner-Tarbes, Sergio
Charleston, Bryan
Fraile, Lorenzo
Tchilian, Elma
Fecha de publicación
2020-09-16ISSN
1664-3224
Resumen
Despite the role of pigs as a source of new Influenza A Virus viruses (IAV) potentially capable of initiating human pandemics, immune responses to swine influenza virus (SwIV) in pigs are not fully understood. Several SwIV epitopes presented by swine MHC (SLA) class I have been identified using different approaches either in outbred pigs or in Babraham large white inbred pigs, which are 85% identical by genome wide SNP analysis. On the other hand, some class II SLA epitopes were recently described in outbred pigs. In this work, Babraham large white inbred pigs were selected to identify SLA II epitopes from SwIV H1N1. PBMCs were screened for recognition of overlapping peptides covering the NP and M1 proteins from heterologous IAV H1N1 in IFNγ ELISPOT. A novel SLA class II restricted epitope was identified in NP from swine H1N1. This conserved novel epitope could be the base for further vaccine approaches against H1N1 in pigs.
Tipo de documento
Artículo
Versión del documento
Versión publicada
Lengua
Inglés
Materias (CDU)
619 - Veterinaria
Páginas
11
Publicado por
Frontiers Media
Publicado en
Frontiers in Immunology
Citación
Baratelli, Massimiliano, Sophie Morgan, Johanneke Dinie Hemmink, Elizabeth Reid, Brigid Veronica Carr, Eric Lefevre, and Sergio Montaner-Tarbes et al. 2020. "Identification Of A Newly Conserved SLA-II Epitope In A Structural Protein Of Swine Influenza Virus". Frontiers In Immunology 11. doi:10.3389/fimmu.2020.02083.
Número del acuerdo de la subvención
EC/FP7/228394/EU/The Network of Animal Disease Infectiology Research Facilities/NADIR
MICINN/Programa Nacional de Proyectos de Investigación Fundamental/AGL2010-22200-C02-01/ES/CARACTERIZACION DE LA RESPUESTA INMUNE INDUCIDA POR CEPAS DEL VIRUS DE LA GRIPE PORCINA CIRCULANTES EN ESPAÑA. DESARROLLO DE VACUNAS BASADAS EN VLPS QUIMERICAS/
Program
Sanitat Animal
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