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dc.contributor.authorSánchez-González, Raúl
dc.contributor.authorRamis, Antonio
dc.contributor.authorNofrarías, Miquel
dc.contributor.authorWali, Nabil
dc.contributor.authorValle, Rosa
dc.contributor.authorPérez, Mónica
dc.contributor.authorPerlas, Albert
dc.contributor.authorMajó, Natàlia
dc.contributor.otherProducció Animalca
dc.date.accessioned2021-02-22T08:36:37Z
dc.date.available2021-02-22T08:36:37Z
dc.date.issued2020-09-10
dc.identifier.citationSánchez-González, Raúl, Antonio Ramis, Miquel Nofrarías, Nabil Wali, Rosa Valle, Mónica Pérez, Albert Perlas, and Natàlia Majó. 2020. "Pathobiology Of The Highly Pathogenic Avian Influenza Viruses H7N1 And H5N8 In Different Chicken Breeds And Role Of Mx 2032 G/A Polymorphism In Infection Outcome". Veterinary Research 51 (1). doi:10.1186/s13567-020-00835-4.ca
dc.identifier.issn0928-4249ca
dc.identifier.urihttp://hdl.handle.net/20.500.12327/1120
dc.description.abstractChickens are highly susceptible to highly pathogenic avian infuenza viruses (HPAIVs). However, the severity of infec‑ tion varies depending of the viral strain and the genetic background of the host. In this study, we evaluated the pathogenesis of two HPAIVs (H7N1 and H5N8) and assessed the susceptibility to the infection of local and com‑ mercial chicken breeds from Spain. Eight chicken breeds were intranasally inoculated with 105 ELD50 of A/Chicken/ Italy/5093/1999 (H7N1) or A/Goose/Spain/IA17CR02699/2017 (H5N8 clade 2.3.4.4. B) and monitored during 10 days. Chickens were highly susceptible to both HPAIVs, but H7N1 was considerably more virulent than H5N8 as demon‑ strated by the highest mortality rates and shortest mean death times (MDT). Both HPAIVs produced severe necrosis and intense viral replication in the central nervous system, heart and pancreas; however, the lesions and replication in other tissues were virus-dependent. High levels of viral RNA were detected by the oral route with both viruses. In contrast, a low number of H5N8-inoculated chickens shed by the cloacal route, demonstrating a diferent pattern of viral shedding dependent of the HPAIV. We found a high variation in the susceptibility to HPAIVs between the diferent chicken breeds. The birds carrying the genotype AA and AG at position 2032 in chicken Mx gene presented a slightly higher, but not signifcant, percentage of survival and a statistically signifcant longer MDT than GG individuals. Our study demonstrated that the severity of HPAI infection is largely dependent of the viral isolate and host factors, under‑ lining the complexity of HPAI infectionsca
dc.format.extent13ca
dc.language.isoengca
dc.publisherBMCca
dc.relation.ispartofVeterinary Researchca
dc.rightsAttribution 4.0 Internationalca
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titlePathobiology of the highly pathogenic avian influenza viruses H7N1 and H5N8 in different chicken breeds and role of Mx 2032 G/A polymorphism in infection outcomeca
dc.typeinfo:eu-repo/semantics/articleca
dc.description.versioninfo:eu-repo/semantics/publishedVersionca
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.termscapca
dc.relation.projectIDMINECO/Programa Estatal de I+D+I orientada a los retos de la sociedad/RTA2015-00088-C03-03/ES/Influenza aviar: Estudio de la dinámica de la infección en aves autóctonas y de persistencia del virus en condiciones ambientales/ca
dc.subject.udc619ca
dc.identifier.doihttps://doi.org/10.1186/s13567-020-00835-4ca
dc.contributor.groupSanitat Animalca


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Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/