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dc.contributor.authorTrinité, Benjamin
dc.contributor.authorTarrés-Freixas, Ferran
dc.contributor.authorRodon, Jordi
dc.contributor.authorPradenas, Edwards
dc.contributor.authorUrrea, Víctor
dc.contributor.authorMarfil, Silvia
dc.contributor.authorRodríguez de la Concepción, María Luisa
dc.contributor.authorÁvila-Nieto, Carlos
dc.contributor.authorAguilar-Gurrieri, Carmen
dc.contributor.authorBarajas, Ana
dc.contributor.authorOrtiz, Raquel
dc.contributor.authorParedes, Roger
dc.contributor.authorMateu, Lourdes
dc.contributor.authorValencia, Alfonso
dc.contributor.authorGuallar, Víctor
dc.contributor.authorRuiz, Lidia
dc.contributor.authorGrau, Eulàlia
dc.contributor.authorMassanella, Marta
dc.contributor.authorPuig, Jordi
dc.contributor.authorChamorro, Anna
dc.contributor.authorIzquierdo-Useros, Nuria
dc.contributor.authorSegalés, Joaquim
dc.contributor.authorClotet, Bonaventura
dc.contributor.authorCarrillo, Jorge
dc.contributor.authorVergara-Alert, Júlia
dc.contributor.authorBlanco, Julià
dc.contributor.otherProducció Animalca
dc.date.accessioned2021-03-26T11:10:24Z
dc.date.available2021-03-26T11:10:24Z
dc.date.issued2021-01-28
dc.identifier.citationTrinité, Benjamin, Ferran Tarrés-Freixas, Jordi Rodon, Edwards Pradenas, Víctor Urrea, Silvia Marfil, and María Luisa Rodríguez de la Concepción et al. 2021. "SARS-Cov-2 Infection Elicits A Rapid Neutralizing Antibody Response That Correlates With Disease Severity". Scientific Reports 11 (1). doi:10.1038/s41598-021-81862-9.ca
dc.identifier.issn2045-2322ca
dc.identifier.urihttp://hdl.handle.net/20.500.12327/1226
dc.description.abstractThe protective effect of neutralizing antibodies in SARS-CoV-2 infected individuals is not yet well defined. To address this issue, we have analyzed the kinetics of neutralizing antibody responses and their association with disease severity. Between March and May 2020, the prospective KING study enrolled 72 COVID-19+ participants grouped according to disease severity. SARS-CoV-2 infection was diagnosed by serological and virological tests. Plasma neutralizing responses were assessed against replicative virus and pseudoviral particles. Multiple regression and non-parametric tests were used to analyze dependence of parameters. The magnitude of neutralizing titers significantly increased with disease severity. Hospitalized individuals developed higher titers compared to mild-symptomatic and asymptomatic individuals, which together showed titers below the detection limit in 50% of cases. Longitudinal analysis confirmed the strong differences in neutralizing titers between non-hospitalized and hospitalized participants and showed rapid kinetics of appearance of neutralizing antibodies (50% and 80% of maximal activity reached after 11 and 17 days after symptoms onset, respectively) in hospitalized patients. No significant impact of age, gender or treatment on the neutralizing titers was observed in this limited cohort. These data identify a clear association of humoral immunity with disease severity and point to immune mechanisms other than antibodies as relevant players in COVID-19 protection.ca
dc.format.extent10ca
dc.language.isoengca
dc.publisherNature Researchca
dc.relation.ispartofScientific Reportsca
dc.rightsAttribution 4.0 Internationalca
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleSARS-CoV-2 infection elicits a rapid neutralizing antibody response that correlates with disease severityca
dc.typeinfo:eu-repo/semantics/articleca
dc.description.versioninfo:eu-repo/semantics/publishedVersionca
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.termscapca
dc.subject.udc619ca
dc.identifier.doihttps://doi.org/10.1038/s41598-021-81862-9ca
dc.contributor.groupSanitat Animalca


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Attribution 4.0 International
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/
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