dc.contributor.author | López-Serrano, Sergi | |
dc.contributor.author | Neila-Ibáñez, Carlos | |
dc.contributor.author | Costa-Hurtado, Mar | |
dc.contributor.author | Mahmmod, Yasser | |
dc.contributor.author | Martínez-Martínez, Jorge | |
dc.contributor.author | Galindo-Cardiel, Iván José | |
dc.contributor.author | Darji, Ayub | |
dc.contributor.author | Rodríguez, Fernando | |
dc.contributor.author | Sibila, Marina | |
dc.contributor.author | Aragon, Virginia | |
dc.contributor.other | Producció Animal | ca |
dc.date.accessioned | 2021-09-28T09:15:44Z | |
dc.date.available | 2021-09-28T09:15:44Z | |
dc.date.issued | 2021-05-20 | |
dc.identifier.citation | López-Serrano, Sergi, Carlos Neila-Ibáñez, Mar Costa-Hurtado, Yasser Mahmmod, Jorge Martínez-Martínez, Iván José Galindo-Cardiel, Ayub Darji, Fernando Rodríguez, Marina Sibila, and Virginia Aragon. 2021. "Sow Vaccination With A Protein Fragment Against Virulent Glaesserella (Haemophilus) Parasuis Modulates Immunity Traits In Their Offspring". Vaccines 9 (5): 534. doi:10.3390/vaccines9050534. | ca |
dc.identifier.issn | 2076-393X | ca |
dc.identifier.uri | http://hdl.handle.net/20.500.12327/1352 | |
dc.description.abstract | Glaesserella (Haemophilus) parasuis, an early colonizer of the nasal cavity in piglets, is a highly heterogeneous species, comprising both commensal and virulent strains. Virulent G. parasuis strains can cause fibrinous polyserositis called Glässer's disease. Colostrum is a source of passive immunity for young piglets. When vaccinating sows, protective antibodies are transferred to their offspring through the colostrum. Here, sow vaccination was performed with a protein fragment, F4, from the outer membrane trimeric autotransporters VtaAs exclusively found in virulent G. parasuis. Piglets were allowed to suckle for 3 weeks, following which a challenge with two virulent strains of G. parasuis was performed. A group of nonvaccinated sows and their piglets were included as a control. Antibodies against F4 were confirmed using ELISA in the vaccinated sows and their offspring before the G. parasuis challenge. Compared to the control group, F4-vaccination also resulted in an increased level of serum TGF-β both in vaccinated sows and in their offspring at early time points of life. After the challenge, a lower body temperature and a higher weight were observed in the group of piglets from vaccinated sows. One piglet from the non-vaccinated group succumbed to the infection, but no other significant differences in clinical signs were noticed. At necropsy, performed 2 weeks after the virulent challenge, the level of surfactant protein D (SP-D) in bronchoalveolar lavage was higher in the piglets from vaccinated sows. Vaccination did not inhibit the nasal colonization of the piglets by the challenge strains. | ca |
dc.format.extent | 14 | ca |
dc.language.iso | eng | ca |
dc.publisher | MDPI | ca |
dc.relation.ispartof | Vaccines | ca |
dc.rights | Attribution 4.0 International | ca |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.title | Sow Vaccination with a Protein Fragment against Virulent Glaesserella (Haemophilus) parasuis Modulates Immunity Traits in Their Offspring | ca |
dc.type | info:eu-repo/semantics/article | ca |
dc.description.version | info:eu-repo/semantics/publishedVersion | ca |
dc.rights.accessLevel | info:eu-repo/semantics/openAccess | |
dc.embargo.terms | cap | ca |
dc.relation.projectID | MINECO/Programa Estatal de I+D+I orientada a los retos de la Sociedad/AGL2016-77361-R/ES/PAPEL DE LA MICROBIOTA RESPIRATORIA EN LA PREVENCION DE LAS ENFERMEDADES CAUSADAS POR LOS COLONIZADORES PRECOCES DEL TRACTO RESPIRATORIO SUPERIOR DEL CERDO/ | ca |
dc.subject.udc | 619 | ca |
dc.identifier.doi | https://doi.org/10.3390/vaccines9050534 | ca |
dc.contributor.group | Sanitat Animal | ca |