Sow Vaccination with a Protein Fragment against Virulent Glaesserella (Haemophilus) parasuis Modulates Immunity Traits in Their Offspring
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Autor/a
Neila-Ibáñez, Carlos
Costa-Hurtado, Mar
Mahmmod, Yasser
Martínez-Martínez, Jorge
Galindo-Cardiel, Iván José
Rodríguez, Fernando
Fecha de publicación
2021-05-20ISSN
2076-393X
Resumen
Glaesserella (Haemophilus) parasuis, an early colonizer of the nasal cavity in piglets, is a highly heterogeneous species, comprising both commensal and virulent strains. Virulent G. parasuis strains can cause fibrinous polyserositis called Glässer's disease. Colostrum is a source of passive immunity for young piglets. When vaccinating sows, protective antibodies are transferred to their offspring through the colostrum. Here, sow vaccination was performed with a protein fragment, F4, from the outer membrane trimeric autotransporters VtaAs exclusively found in virulent G. parasuis. Piglets were allowed to suckle for 3 weeks, following which a challenge with two virulent strains of G. parasuis was performed. A group of nonvaccinated sows and their piglets were included as a control. Antibodies against F4 were confirmed using ELISA in the vaccinated sows and their offspring before the G. parasuis challenge. Compared to the control group, F4-vaccination also resulted in an increased level of serum TGF-β both in vaccinated sows and in their offspring at early time points of life. After the challenge, a lower body temperature and a higher weight were observed in the group of piglets from vaccinated sows. One piglet from the non-vaccinated group succumbed to the infection, but no other significant differences in clinical signs were noticed. At necropsy, performed 2 weeks after the virulent challenge, the level of surfactant protein D (SP-D) in bronchoalveolar lavage was higher in the piglets from vaccinated sows. Vaccination did not inhibit the nasal colonization of the piglets by the challenge strains.
Tipo de documento
Artículo
Versión del documento
Versión publicada
Lengua
English
Materias (CDU)
619 - Veterinaria
Páginas
14
Publicado por
MDPI
Publicado en
Vaccines
Citación
López-Serrano, Sergi, Carlos Neila-Ibáñez, Mar Costa-Hurtado, Yasser Mahmmod, Jorge Martínez-Martínez, Iván José Galindo-Cardiel, Ayub Darji, Fernando Rodríguez, Marina Sibila, and Virginia Aragon. 2021. "Sow Vaccination With A Protein Fragment Against Virulent Glaesserella (Haemophilus) Parasuis Modulates Immunity Traits In Their Offspring". Vaccines 9 (5): 534. doi:10.3390/vaccines9050534.
Número del acuerdo de la subvención
MINECO/Programa Estatal de I+D+I orientada a los retos de la Sociedad/AGL2016-77361-R/ES/PAPEL DE LA MICROBIOTA RESPIRATORIA EN LA PREVENCION DE LAS ENFERMEDADES CAUSADAS POR LOS COLONIZADORES PRECOCES DEL TRACTO RESPIRATORIO SUPERIOR DEL CERDO/
Program
Sanitat Animal
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