Show simple item record

dc.contributor.authorForner, Mar
dc.contributor.authorCañas-Arranz, Rodrigo
dc.contributor.authorDefaus, Sira
dc.contributor.authorde León, Patricia
dc.contributor.authorRodríguez-Pulido, Miguel
dc.contributor.authorGanges, Llilianne
dc.contributor.authorBlanco, Esther
dc.contributor.authorSobrino, Francisco
dc.contributor.authorAndreu, David
dc.contributor.otherProducció Animalca
dc.date.accessioned2021-09-28T12:11:24Z
dc.date.available2021-09-28T12:11:24Z
dc.date.issued2021-05-08
dc.identifier.citationForner, Mar, Rodrigo Cañas-Arranz, Sira Defaus, Patricia de León, Miguel Rodríguez-Pulido, Llilianne Ganges, Esther Blanco, Francisco Sobrino, and David Andreu. 2021. "Peptide-Based Vaccines: Foot-And-Mouth Disease Virus, A Paradigm In Animal Health". Vaccines 9 (5): 477. doi:10.3390/vaccines9050477.ca
dc.identifier.issn2076-393Xca
dc.identifier.urihttp://hdl.handle.net/20.500.12327/1360
dc.description.abstractVaccines are considered one of the greatest global health achievements, improving the welfare of society by saving lives and substantially reducing the burden of infectious diseases. However, few vaccines are fully effective, for reasons ranging from intrinsic limitations to more contingent shortcomings related, e.g., to cold chain transport, handling and storage. In this context, subunit vaccines where the essential antigenic traits (but not the entire pathogen) are presented in rationally designed fashion have emerged as an attractive alternative to conventional ones. In particular, this includes the option of fully synthetic peptide vaccines able to mimic well-defined B- and T-cell epitopes from the infectious agent and to induce protection against it. Although, in general, linear peptides have been associated to low immunogenicity and partial protection, there are several strategies to address such issues. In this review, we report the progress towards the development of peptide-based vaccines against foot-and-mouth disease (FMD) a highly transmissible, economically devastating animal disease. Starting from preliminary experiments using single linear B-cell epitopes, recent research has led to more complex and successful second-generation vaccines featuring peptide dendrimers containing multiple copies of B- and T-cell epitopes against FMD virus or classical swine fever virus (CSFV). The usefulness of this strategy to prevent other animal and human diseases is discussed.ca
dc.format.extent21ca
dc.language.isoengca
dc.publisherMDPIca
dc.relation.ispartofVaccinesca
dc.rightsAttribution 4.0 Internationalca
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titlePeptide-Based Vaccines: Foot-and-Mouth Disease Virus, a Paradigm in Animal Healthca
dc.typeinfo:eu-repo/semantics/articleca
dc.description.versioninfo:eu-repo/semantics/publishedVersionca
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.termscapca
dc.relation.projectIDEC/H2020/828774/EU/”One size fits all'' unique drug to eradicate multiple viral species simultaneously from the central nervous system of co-infected individuals/NOVIRUSES2BRAINca
dc.relation.projectIDMINECO/Programa Estatal de I+D+I orientada a los retos de la sociedad/AGL2013-48923-C2-2-R/ES/Nuevas estrategias vacunales frente a enfermedades víricas ganaderas empleando pseudopartículas virales modificadas/ca
dc.relation.projectIDMINECO/Programa Estatal de I+D+I orientada a los retos de la sociedad/AGL2017-84097-C2-2-R/ES/Construcciones vacunales peptídicas mono y multivalentes contra la fiebre aftosa: producción optimizada y estudios de estructura, estabilidad y biodistribución/ca
dc.relation.projectIDMINECO/Programa Estatal de I+D+I orientada a los retos de la sociedad/AGL2016-76445-R/ES/Modulación de la respuesta immune inducida por pseudopartículas virales; avances en la mejora del control de las enfermedades víricas del ganado/ca
dc.subject.udc619ca
dc.identifier.doihttps://doi.org/10.3390/vaccines9050477ca
dc.contributor.groupSanitat Animalca


Files in this item

 

This item appears in the following Collection(s)

Show simple item record

Attribution 4.0 International
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/