Understanding host-microbiota interactions in the commercial piglet around weaning
Autor/a
Saladrigas-García, M.
D’Angelo, M.
Ko, H.L.
Nolis, P.
Ramayo-Caldas, Y.
Folch, J.M.
Llonch, P.
Solà-Oriol, D.
Pérez, J.F.
Martín-Orúe, S.M.
Fecha de publicación
2021-12-06ISSN
2045-2322
Resumen
Weaning is a critical period in the life of pigs with repercussions on their health and welfare and on the
economy of the swine industry. This study aimed to assess the efect of the commercial early weaning
on gut microbiota, intestinal gene expression and serum metabolomic response via an integratedomic approach combining 16S rRNA gene sequencing, the OpenArray gene expression technology and
1
H-NMR spectroscopy. Fourteen piglets from diferent litters were sampled for blood, jejunum tissue
and caecal content two days before (− 2d), and three days after (+3d) weaning. A clearly diferential
ordination of caecal microbiota was observed. Higher abundances of Roseburia, Ruminococcus,
Coprococcus, Dorea and Lachnospira genera in weaned piglets compared to prior to weaning showed
the quick microbial changes of the piglets’ gut microbiota. Downregulation of OCLN, CLDN4, MUC2,
MUC13, SLC15A1 and SLC13A1 genes, also evidenced the negative impact of weaning on gut barrier
and digestive functions. Metabolomic approach pinpointed signifcant decreases in choline, LDL,
triglycerides, fatty acids, alanine and isoleucine and increases in 3-hydroxybutyrate after weaning.
Moreover, the correlation between microbiota and metabolome datasets revealed the existence of
metabolic clusters interrelated to diferent bacterial clusters. Our results demonstrate the impact of
weaning stress on the piglet and give insights regarding the associations between gut microbiota and
the animal gene activity and metabolic response.
Tipo de documento
Artículo
Versión del documento
Versión publicada
Lengua
English
Materias (CDU)
619 - Veterinaria
Páginas
18
Publicado por
Nature Research
Publicado en
Scientific reports
Citación
Saladrigas-García, M., M. D’Angelo, H. L. Ko, P. Nolis, Y. Ramayo-Caldas, J. M. Folch, P. Llonch, D. Solà-Oriol, J. F. Pérez, and S. M. Martín-Orúe. 2021. "Understanding Host-Microbiota Interactions In The Commercial Piglet Around Weaning". Scientific Reports 11 (1). doi:10.1038/s41598-021-02754-6.
Número del acuerdo de la subvención
MINECO/Programa Estatal de I+D+I orientada a los retos de la sociedad/AGL2016-75463/ES/DETERMINISMO TEMPRANO EN LOS LECHONES: UNA OPORTUNIDAD PARA CONDICIONAR SU RESPUESTA TRAS EL DESTETE. ESTUDIO DE LOS MECANISMOS IMPLICADOS/
MINECO/Programa Estatal de promoción del talento y su empleabilidad en I+D+I/BES-2017-080018/ES/ /
EC/H2020/665992/EU/MSCA FIRE: Fellows with Industrial Research Enhancement/MSCA FIRE
MICIU-FEDER/Programa Estatal de promoción del talento y su empleabilidad en I+D+I/RYC2019-027244-I/ES/ /
Program
Genètica i Millora Animal
Este ítem aparece en la(s) siguiente(s) colección(ones)
- ARTICLES CIENTÍFICS [2811]
Excepto si se señala otra cosa, la licencia del ítem se describe como http://creativecommons.org/licenses/by/4.0/