Maximum levels of cross-contamination for 24 antimicrobial active substances in non-target feed. Part 1: Methodology, general data gaps and uncertainties
Visualitza/Obre
Autor/a
EFSA Panel on Biological Hazards (BIOHAZ)
Koutsoumanis, Konstantinos
Allende, Ana
Alvarez-Ordóñez, Avelino
Bolton, Declan
Bover-Cid, Sara
Chemaly, Marianne
Davies, Robert
De Cesare, Alessandra
Herman, Lieve
Hilbert, Friederike
Lindqvist, Roland
Nauta, Maarten
Ru, Giuseppe
Simmons, Marion
Skandamis, Panagiotis
Suffredini, Elisabetta
Andersson, Dan I
Bampidis, Vasileios
Bengtsson-Palme, Johan
Bouchard, Damien
Ferran, Aude
Kouba, Maryline
López Puente, Secundino
López-Alonso, Marta
Nielsen, Søren Saxmose
Pechová, Alena
Petkova, Mariana
Girault, Sebastien
Broglia, Alessandro
Guerra, Beatriz
Innocenti, Matteo Lorenzo
Liébana, Ernesto
López-Gálvez, Gloria
Manini, Paola
Stella, Pietro
Peixe, Luisa
Data de publicació
2021-10-26ISSN
1831-4732
Resum
The European Commission requested EFSA to assess, in collaboration with EMA, the specific concentrations of antimicrobials resulting from cross-contamination in non-target feed for food-producing animals below which there would not be an effect on the emergence of, and/or selection for, resistance in microbial agents relevant for human and animal health, as well as the levels of the antimicrobials which could have a growth promotion/increase yield effect. The assessment was performed for 24 antimicrobial active substances, as specified in the mandate. This scientific opinion describes the methodology used, and the main associated data gaps and uncertainties. To estimate the antimicrobial levels in the non-target feed that would not result in emergence of, and/or selection for, resistance, a model was developed. This ‘Feed Antimicrobial Resistance Selection Concentration’ (FARSC) model is based on the minimal selective concentration (MSC), or the predicted MSC (PMSC) if MSC for the most susceptible bacterial species is unavailable, the fraction of antimicrobial dose available for exposure to microorganisms in the large intestine or rumen (considering pharmacokinetic parameters), the daily faecal output or rumen volume and the daily feed intake. Currently, lack of data prevents the establishment of PMSC and/or FARSC for several antimicrobials and animal species. To address growth promotion, data from an extensive literature search were used. Specific assessments of the different substances grouped by antimicrobial classes are addressed in separate scientific opinions. General conclusions and recommendations were made.
Tipus de document
Article
Versió del document
Versió publicada
Llengua
English
Matèries (CDU)
663/664 - Aliments i nutrició. Enologia. Olis. Greixos
Pàgines
57
Publicat per
Wiley Open Access
Publicat a
EFSA Journal
Citació
Koutsoumanis, Konstantinos, Ana Allende, Avelino Alvarez‐Ordóñez, Declan Bolton, Sara Bover‐Cid, Marianne Chemaly, and Robert Davies et al. 2021. "Maximum Levels Of Cross‐Contamination For 24 Antimicrobial Active Substances In Non‐Target Feed. Part 1: Methodology, General Data Gaps And Uncertainties". EFSA Journal 19 (10). doi:10.2903/j.efsa.2021.6852.
Programa
Funcionalitat i Seguretat Alimentària
Aquest element apareix en la col·lecció o col·leccions següent(s)
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