dc.contributor.author | Bohórquez, José Alejandro | |
dc.contributor.author | Defaus, Sira | |
dc.contributor.author | Rosell, Rosa | |
dc.contributor.author | Pérez-Simó, Marta | |
dc.contributor.author | Alberch, Mònica | |
dc.contributor.author | Gladue, Douglas P. | |
dc.contributor.author | Borca, Manuel V. | |
dc.contributor.author | Andreu, David | |
dc.contributor.author | Ganges, Llilianne | |
dc.contributor.other | Producció Animal | ca |
dc.date.accessioned | 2022-01-24T16:52:31Z | |
dc.date.available | 2022-01-24T16:52:31Z | |
dc.date.issued | 2021-10-02 | |
dc.identifier.citation | Bohórquez, José A., Sira Defaus, Rosa Rosell, Marta Pérez-Simó, Mònica Alberch, Douglas P. Gladue, Manuel V. Borca, David Andreu, and Llilianne Ganges. 2021. "Development of a Dendrimeric Peptide-Based Approach for the Differentiation of Animals Vaccinated with FlagT4G against Classical Swine Fever from Infected Pigs" Viruses 13, no. 10: 1980. https://doi.org/10.3390/v13101980 | ca |
dc.identifier.issn | 1999-4915 | ca |
dc.identifier.uri | http://hdl.handle.net/20.500.12327/1535 | |
dc.description.abstract | Classical swine fever virus (CSFV) causes a viral disease of high epidemiological and
economical significance that affects domestic and wild swine. Control of the disease in endemic
countries is based on live-attenuated vaccines (LAVs) that induce an early protective immune
response against highly virulent CSFV strains. The main disadvantage of these currently available
LAVs is the lack of serological techniques to differentiate between vaccinated and infected animals
(DIVA concept). Here, we describe the development of the FlagDIVA test, a serological diagnostic
tool allowing for the differentiation between animals vaccinated with the FlagT4G candidate and
those infected with CSFV field strains. The FlagDIVA test is a direct ELISA based on a dendrimeric
peptide construct displaying a conserved epitope of CSFV structural protein E2. Although FlagDIVA
detected anti-CSFV anti-bodies in infected animals, it did not recognize the antibody response of
FlagT4G-vaccinated animals. Therefore, the FlagDIVA test constitutes a valuable accessory DIVA
tool in implementing vaccination with the FlagT4G candidate. | ca |
dc.format.extent | 10 | ca |
dc.language.iso | eng | ca |
dc.publisher | MDPI | ca |
dc.relation.ispartof | Viruses | ca |
dc.rights | Attribution 4.0 International | ca |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.title | Development of a Dendrimeric Peptide-Based Approach for the Differentiation of Animals Vaccinated with FlagT4G against Classical Swine Fever from Infected Pigs | ca |
dc.type | info:eu-repo/semantics/article | ca |
dc.description.version | info:eu-repo/semantics/publishedVersion | ca |
dc.rights.accessLevel | info:eu-repo/semantics/openAccess | |
dc.embargo.terms | cap | ca |
dc.relation.projectID | MINECO/Programa estatal de I+D+I orientada a los retos de la sociedad/RTI2018-100887-B-100/ES/Descifrando nuevos factores virales y del hospedador involucrados en el desarrollo de la peste porcina clásica: implicaciones para el control de la enfermedad/ | ca |
dc.subject.udc | 619 | ca |
dc.identifier.doi | https://doi.org/10.3390/v13101980 | ca |
dc.contributor.group | Sanitat Animal | ca |