A Novel E2 Glycoprotein Subunit Marker Vaccine Produced in Plant Is Able to Prevent Classical Swine Fever Virus Vertical Transmission after Double Vaccination
Visualitza/Obre
Autor/a
Park, Youngmin
Oh, Yeonsu
Wang, Miaomiao
Bohórquez, José Alejandro
Park, Soohong
Gu, Sungmin
Park, Jungae
Lee, Sangmin
Kim, Jongkook
Sohn, Eun-Ju
Data de publicació
2021-04-22ISSN
2076-393X
Resum
The efficacy of a novel subunit vaccine candidate, based in the CSFV E2 glycoprotein
produced in plants to prevent classical swine fever virus (CSFV) vertical transmission, was evaluated.
A Nicotiana benthamiana tissue culture system was used to obtain a stable production of the E2-
glycoprotein fused to the porcine Fc region of IgG. Ten pregnant sows were divided into three groups:
Groups 1 and 2 (four sows each) were vaccinated with either 100 µg/dose or 300 µg/dose of the
subunit vaccine at 64 days of pregnancy. Group 3 (two sows) was injected with PBS. Groups 1
and 2 were boosted with the same vaccine dose. At 10 days post second vaccination, the sows in
Groups 2 and 3 were challenged with a highly virulent CSFV strain. The vaccinated sows remained
clinically healthy and seroconverted rapidly, showing efficient neutralizing antibodies. The fetuses
from vaccinated sows did not show gross lesions, and all analyzed tissue samples tested negative
for CSFV replication. However, fetuses of non-vaccinated sows had high CSFV replication in tested
tissue samples. The results suggested that in vaccinated sows, the plant produced E2 marker vaccine
induced the protective immunogenicity at challenge, leading to protection from vertical transmission
to fetuses.
Tipus de document
Article
Versió del document
Versió publicada
Llengua
English
Matèries (CDU)
619 - Veterinària
Pàgines
11
Publicat per
MDPI
Publicat a
Vaccines
Citació
Park, Youngmin, Yeonsu Oh, Miaomiao Wang, Llilianne Ganges, José Alejandro Bohórquez, Soohong Park, and Sungmin Gu et al. 2021. "A Novel E2 Glycoprotein Subunit Marker Vaccine Produced In Plant Is Able To Prevent Classical Swine Fever Virus Vertical Transmission After Double Vaccination". Vaccines 9 (5): 418. doi:10.3390/vaccines9050418.
Programa
Sanitat Animal
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