Grifola frondosa (Maitake) Extract Reduces Fat Accumulation and Improves Health Span in C. elegans through the DAF-16/FOXO and SKN-1/NRF2 Signalling Pathways
Fabra, María José
Milagro, Fermín I.
González-Navarro, Carlos J.
In recent years, food ingredients rich in bioactive compounds have emerged as candidates to prevent excess adiposity and other metabolic complications characteristic of obesity, such as low-grade inflammation and oxidative status. Among them, fungi have gained popularity for their high polysaccharide content and other bioactive components with beneficial activities. Here, we use the C. elegans model to investigate the potential activities of a Grifola frondosa extract (GE), together with the underlying mechanisms of action. Our study revealed that GE represents an important source of polysaccharides and phenolic compounds with in vitro antioxidant activity. Treatment with our GE extract, which was found to be nongenotoxic through a SOS/umu test, significantly reduced the fat content of C. elegans, decreased the production of intracellular ROS and aging–lipofuscin pigment, and increased the lifespan of nematodes. Gene expression and mutant analyses demonstrated that the in vivo anti-obesity and antioxidant activities of GE were mediated through the daf-2/daf-16 and skn-1/nrf-2 signalling pathways, respectively. Taken together, our results suggest that our GE extract could be considered a potential functional ingredient for the prevention of obesity-related disturbances.
663/664 - Aliments i nutrició. Enologia. Olis. Greixos
Is part of
Aranaz, Paula, Adriana Peña, Ariane Vettorazzi, María José Fabra, Antonio Martínez-Abad, Amparo López-Rubio, and Joan Pera et al. 2021. "Grifola Frondosa (Maitake) Extract Reduces Fat Accumulation And Improves Health Span In C. Elegans Through The DAF-16/FOXO And SKN-1/NRF2 Signalling Pathways". Nutrients 13 (11): 3968. doi:10.3390/nu13113968.
Grant agreement number
CDTI/IDI-20170863/ES/Obtención de Componentes bioactivos para el sector agroalimentario mediante procesos de bioconversión y biorrefinería de subproductes de origen animal y vegetal. (2/8)/BIOPRO
Protecció Vegetal Sostenible
Funcionalitat i Seguretat Alimentària
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- ARTICLES CIENTÍFICS 
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Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/